Drug development

Peter S. R. Wright, Katharine A. Briggs, Robert Thomas, et al. Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database. Regulatory Toxicology and Pharmacology. 2023;138:105308. doi:10.1016/j.yrtph.2022.105308

Duxin Sun, Wei Gao, Hongxiang Hu, Simon Zhou. Why 90% of clinical drug development fails and how to improve it? Acta Pharmaceutica Sinica B. 2022;12(7):3049-3062. doi:10.1016/j.apsb.2022.02.002

Jack W. Scannell, James Bosley, John A. Hickman, et al. Predictive validity in drug discovery: what it is, why it matters and how to improve it. Nature Reviews Drug Discovery. 2022;21(12):915-931. doi:10.1038/s41573-022-00552-x

Emily Sutterby, Peter Thurgood, Sara Baratchi, Khashayar Khoshmanesh, Elena Pirogova. Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities. VIEW. 2022;3(2):20210012. doi:10.1002/VIW.20210012

Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Wouter P. C. Boon, et al. Tradition, not science, is the basis of animal model selection in translational and applied research. ALTEX. 2021;38(1):49-62. doi:10.14573/altex.2003301

Lorna Ewart, Adrian Roth. Opportunities and challenges with microphysiological systems: a pharma end-user perspective. Nature Reviews. Drug Discovery. 2021;20(5):327-328. doi:10.1038/d41573-020-00030-2

Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, et al. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research. 2021;117(14):2742-2754. doi:10.1093/cvr/cvab088

Argus M. Sun, Tyler Hoffman, Bao Q. Luu, Nureddin Ashammakhi, Song Li. Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review. Bio-Design and Manufacturing. 2021;4(4):757-775. doi:10.1007/s42242-021-00136-5

David B. Chou, Viktoras Frismantas, Yuka Milton, et al. On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature Biomedical Engineering. 2020;4(4):394-406. doi:10.1038/s41551-019-0495-z

Uwe Marx, Takafumi Akabane, Tommy B. Andersson, et al. Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX. 2020;37(3):365-394. doi:10.14573/altex.2001241