Drug development

Emily Sutterby, Peter Thurgood, Sara Baratchi, Khashayar Khoshmanesh, Elena Pirogova. Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities. VIEW. 2022;3(2):20210012. doi:10.1002/VIW.20210012

Jack W. Scannell, James Bosley, John A. Hickman, et al. Predictive validity in drug discovery: what it is, why it matters and how to improve it. Nature Reviews Drug Discovery. 2022;21(12):915-931. doi:10.1038/s41573-022-00552-x

Lorna Ewart, Adrian Roth. Opportunities and challenges with microphysiological systems: a pharma end-user perspective. Nature Reviews. Drug Discovery. 2021;20(5):327-328. doi:10.1038/d41573-020-00030-2

Argus M. Sun, Tyler Hoffman, Bao Q. Luu, Nureddin Ashammakhi, Song Li. Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review. Bio-Design and Manufacturing. 2021;4(4):757-775. doi:10.1007/s42242-021-00136-5

Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, et al. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research. 2021;117(14):2742-2754. doi:10.1093/cvr/cvab088

Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Wouter P. C. Boon, et al. Tradition, not science, is the basis of animal model selection in translational and applied research. ALTEX. 2021;38(1):49-62. doi:10.14573/altex.2003301

S. Vincent Rajkumar. The high cost of prescription drugs: causes and solutions. Blood Cancer Journal. 2020;10(6):71. doi:10.1038/s41408-020-0338-x

Uwe Marx, Takafumi Akabane, Tommy B. Andersson, et al. Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX. 2020;37(3):365-394. doi:10.14573/altex.2001241

David B. Chou, Viktoras Frismantas, Yuka Milton, et al. On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature Biomedical Engineering. 2020;4(4):394-406. doi:10.1038/s41551-019-0495-z

Aroon D. Hingorani, Valerie Kuan, Chris Finan, et al. Improving the odds of drug development success through human genomics: modelling study. Scientific Reports. 2019;9(1):18911. doi:10.1038/s41598-019-54849-w