Drug development

Ingrid Berg, Pia Härvelid, Wolfgang Emanuel Zürrer, Marianna Rosso, Daniel S. Reich, Benjamin Victor Ineichen. Which experimental factors govern successful animal-to-human translation in multiple sclerosis drug development? A systematic review and meta-analysis. eBioMedicine. 2024;110. doi:10.1016/j.ebiom.2024.105434

Thomas Hartung. The (misleading) role of animal models in drug development. Frontiers in Drug Discovery. 2024;4. doi:10.3389/fddsv.2024.1355044

Pelin L. Candarlioglu, Louise Delsing, Lauren Gauthier, et al. Application of microphysiological systems for nonclinical evaluation of cell therapies. Alternatives to Animal Experimentation. 2024;41(3):469-484. doi:10.14573/altex.2402201

Peter S. R. Wright, Katharine A. Briggs, Robert Thomas, et al. Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database. Regulatory Toxicology and Pharmacology. 2023;138:105308. doi:10.1016/j.yrtph.2022.105308

Katerina Trajanoska, Claude Bhérer, Daniel Taliun, Sirui Zhou, J. Brent Richards, Vincent Mooser. From target discovery to clinical drug development with human genetics. Nature. 2023;620(7975):737-745. doi:10.1038/s41586-023-06388-8

Julia Y. Co, Jessica A. Klein, Serah Kang, Kimberly A. Homan. Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids. Advanced Biology. 2023;7(12):2200333. doi:10.1002/adbi.202200333

Marit Keuper-Navis, Markus Walles, Birk Poller, et al. The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development. Pharmacological Research. 2023;195:106853. doi:10.1016/j.phrs.2023.106853

Carla Cuní-López, Romal Stewart, Anthony R. White, Hazel Quek. 3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases. Journal of Neuroimmunology. 2023;375:578017. doi:10.1016/j.jneuroim.2023.578017

Kimberly A. Homan. Industry Adoption of Organoids and Organs-on-Chip Technology: Toward a Paradox of Choice. Advanced Biology. 2023;7(6):2200334. doi:10.1002/adbi.202200334

Duxin Sun, Wei Gao, Hongxiang Hu, Simon Zhou. Why 90% of clinical drug development fails and how to improve it? Acta Pharmaceutica Sinica B. 2022;12(7):3049-3062. doi:10.1016/j.apsb.2022.02.002