Translation and validation

Isabella WY Mak, Nathan Evaniew, Michelle Ghert. Lost in translation: animal models and clinical trials in cancer treatment. American Journal of Translational Research. 2014;6(2):114-118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/.

Jeffrey L. Cummings, Travis Morstorf, Kate Zhong. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimer’s Research & Therapy. 2014;6:37. doi:10.1186/alzrt269

Pandora Pound, Michael B. Bracken. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ. 2014;348:g3387. doi:10.1136/bmj.g3387

Jarrod Bailey, Michelle Thew, Michael Balls. An analysis of the use of animal models in predicting human toxicology and drug safety. Alternatives to Laboratory Animals. 2014;42(3):181-199. doi:10.1177/026119291404200306

Fiona Godlee. How predictive and productive is animal research? BMJ. 2014;348:g3719. doi:10.1136/bmj.g3719

Jennifer A. Hirst, Jeremy Howick, Jeffrey K. Aronson, et al. The need for randomization in animal trials: an overview of systematic reviews. PloS One. 2014;9(6):e98856. doi:10.1371/journal.pone.0098856

Jarrod Bailey. Monkey-based research on human disease: the implications of genetic differences. Alternatives to Laboratory Animals. 2014;42(5):287-317. doi:10.1177/026119291404200504

Michael Hay, David W. Thomas, John L. Craighead, Celia Economides, Jesse Rosenthal. Clinical development success rates for investigational drugs. Nature Biotechnology. 2014;32:40-51. doi:10.1038/nbt.2786

Joseph P. Garner. The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It? ILAR Journal. 2014;55(3):438-456. doi:10.1093/ilar/ilu047

Junhee Seok, H. Shaw Warren, Alex G. Cuenca, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proceedings of the National Academy of Sciences. 2013;110(9):3507-3512. doi:10.1073/pnas.1222878110