Gastrointestinal system

Tomoki Imaoka, Reiko Onuki-Nagasaki, Hiroshi Kimura, et al. Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut. Scientific Reports. 2024;14(1):29921. doi:10.1038/s41598-024-80946-6

Amanda J. Oliver, Ni Huang, Raquel Bartolome-Casado, et al. Single-cell integration reveals metaplasia in inflammatory gut diseases. Nature. 2024;635(8039):699-707. doi:10.1038/s41586-024-07571-1

Yu Zhang, Si-Ming Lu, Jian-Jian Zhuang, Li-Guo Liang. Advances in gut–brain organ chips. Cell Proliferation. 2024;57(9):e13724. doi:10.1111/cpr.13724

Longjin Zheng, Yang Zhan, Chenxuan Wang, et al. Technological advances and challenges in constructing complex gut organoid systems. Frontiers in Cell and Developmental Biology. 2024;12. doi:10.3389/fcell.2024.1432744

Victor Calero, Patrícia M. Rodrigues, Tiago Dias, et al. A miniaturised semi-dynamic in-vitro model of human digestion. Scientific Reports. 2024;14:11923. doi:10.1038/s41598-024-54612-w

Thomas W. Dennison, Rachel D. Edgar, Felicity Payne, et al. Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease. Gut. 2024;73:1464-1477. doi:10.1136/gutjnl-2024-332043

Olga Mitrofanova, Mikhail Nikolaev, Quan Xu, et al. Bioengineered human colon organoids with in vivo-like cellular complexity and function. Cell Stem Cell. 2024;31(8):1175-1186.e7. doi:10.1016/j.stem.2024.05.007

Jianbo Zhang, Yu-Ja Huang, Martin Trapecar, et al. An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii. npj Biofilms and Microbiomes. 2024;10(1):1-11. doi:10.1038/s41522-024-00501-z

Vadim Osadchiy, Roshan Bal, Emeran A. Mayer, et al. Machine learning model to predict obesity using gut metabolite and brain microstructure data. Scientific Reports. 2023;13(1):5488. doi:10.1038/s41598-023-32713-2

Wyatt E. Lanik, Cliff J. Luke, Lila S. Nolan, et al. Microfluidic device facilitates in vitro modeling of human neonatal necrotizing enterocolitis–on-a-chip. JCI Insight. 2023;8(8):e146496. doi:10.1172/jci.insight.146496