Gastrointestinal system

Won Dong Yu, Sugi Lee, Hyun-Soo Cho, et al. Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model. Experimental & Molecular Medicine. 2026:1-14. doi:10.1038/s12276-025-01635-6

Nike Walther, Sathvik Anantakrishnan, Gina M. Dailey, Anna C. Maurer, Claudia Cattoglio. Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2025.102787

Maria Letizia Di Martino, Laura Jenniches, Anjeela Bhetwal, et al. A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. Nature Genetics. 2025;57(7):1730-1741. doi:10.1038/s41588-025-02218-x

Jianzhen Ren, Silin Huang. Intestinal Organoids for Inflammatory Bowel Disease. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1517121

Olga Mitrofanova, Mikhail Nikolaev, Quan Xu, et al. Bioengineered human colon organoids with in vivo-like cellular complexity and function. Cell Stem Cell. 2024;31(8):1175-1186.e7. doi:10.1016/j.stem.2024.05.007

Victor Calero, Patrícia M. Rodrigues, Tiago Dias, et al. A miniaturised semi-dynamic in-vitro model of human digestion. Scientific Reports. 2024;14:11923. doi:10.1038/s41598-024-54612-w

Thomas W. Dennison, Rachel D. Edgar, Felicity Payne, et al. Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease. Gut. 2024;73:1464-1477. doi:10.1136/gutjnl-2024-332043

Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, et al. An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells. Cell Reports. 2024;43(7). doi:10.1016/j.celrep.2024.114247

Longjin Zheng, Yang Zhan, Chenxuan Wang, et al. Technological advances and challenges in constructing complex gut organoid systems. Frontiers in Cell and Developmental Biology. 2024;12. doi:10.3389/fcell.2024.1432744

Yu Zhang, Si-Ming Lu, Jian-Jian Zhuang, Li-Guo Liang. Advances in gut–brain organ chips. Cell Proliferation. 2024;57(9):e13724. doi:10.1111/cpr.13724