Gastrointestinal system

Holly M. Poling, Théo Noël, Akaljot Singh, et al. Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement. Nature Biomedical Engineering. 2026:1-17. doi:10.1038/s41551-026-01688-6

Nike Walther, Sathvik Anantakrishnan, Gina M. Dailey, Anna C. Maurer, Claudia Cattoglio. Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2025.102787

Won Dong Yu, Sugi Lee, Hyun-Soo Cho, et al. Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model. Experimental & Molecular Medicine. 2026:1-14. doi:10.1038/s12276-025-01635-6

Alican Özkan, Gwenn E. Merry, David B. Chou, et al. Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects. Nature Biomedical Engineering. 2026:1-14. doi:10.1038/s41551-026-01686-8

Jianzhen Ren, Silin Huang. Intestinal Organoids for Inflammatory Bowel Disease. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1517121

Maria Letizia Di Martino, Laura Jenniches, Anjeela Bhetwal, et al. A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. Nature Genetics. 2025;57(7):1730-1741. doi:10.1038/s41588-025-02218-x

Victor Calero, Patrícia M. Rodrigues, Tiago Dias, et al. A miniaturised semi-dynamic in-vitro model of human digestion. Scientific Reports. 2024;14:11923. doi:10.1038/s41598-024-54612-w

Yu Zhang, Si-Ming Lu, Jian-Jian Zhuang, Li-Guo Liang. Advances in gut–brain organ chips. Cell Proliferation. 2024;57(9):e13724. doi:10.1111/cpr.13724

Longjin Zheng, Yang Zhan, Chenxuan Wang, et al. Technological advances and challenges in constructing complex gut organoid systems. Frontiers in Cell and Developmental Biology. 2024;12. doi:10.3389/fcell.2024.1432744

Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, et al. An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells. Cell Reports. 2024;43(7). doi:10.1016/j.celrep.2024.114247