Cancer

Seth-Frerich Fobian, Mohamadreza Amin, Andrea Sacchetti, Arlene L. Oei, Timo L. M. ten Hagen. Investigating the delivery of PD-L1-targeted immunoliposomes in a dynamic cervical cancer-on-a-chip model. Journal of Controlled Release. 2025;379:236-250. doi:10.1016/j.jconrel.2025.01.014

Irem Duman, Verena Pichler. Modelling metastasis in a dish: in vitro approaches for studying breast cancer progression. Pathology and Oncology Research. 2025;31:1612179. doi:10.3389/pore.2025.1612179

Haijiao Liu, Estela Noguera-Ortega, Xuanqi Dong, et al. A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors. Nature Biotechnology. 2025:1-17. doi:10.1038/s41587-025-02845-z

Carly Strelez, Francesca Battaglin, Rachel Perez, et al. GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancer. Oncogene. 2025:1-15. doi:10.1038/s41388-025-03546-2

Gat Rauner, Piyush B. Gupta, Charlotte Kuperwasser. From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research. Nature Methods. 2025:1-12. doi:10.1038/s41592-025-02769-1

Sanjima Pal, Elee Shimshoni, Salvador Flores Torres, et al. Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology. Journal of Translational Medicine. 2025;23(1):577. doi:10.1186/s12967-025-06593-1

Mattia Ballerini, Serena Galiè, Punit Tyagi, et al. A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma. Nature Biomedical Engineering. 2025:1-18. doi:10.1038/s41551-024-01318-z

Tianping Peng, Xiujian Ma, Wei Hua, et al. Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy. Cell Stem Cell. 2025. doi:10.1016/j.stem.2025.01.002

Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, et al. A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens. Nature Communications. 2025;16(1):1392. doi:10.1038/s41467-024-55129-6

Mustafa Sibai, Sergi Cervilla, Daniela Grases, et al. The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity. Cell Reports. 2025;44(2). doi:10.1016/j.celrep.2024.115229