Cancer

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Jerome Lacombe, Sean E. Dunn, Marie Layac, et al. A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation. iScience. 2026;29(1). doi:10.1016/j.isci.2025.114236
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Pooja Sawant, Ratnesh Jain, Prajakta Dandekar. Emerging therapies for lung adenocarcinoma: Mechanistic and efficacy insights from spheroid-based <i>in vitro</i> models. Journal of Drug Delivery Science and Technology. 2026;117:108030. doi:10.1016/j.jddst.2026.108030
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Weihong Ge, Ryan L. Kan, Can Yilgor, et al. Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1. Cell Reports. 2026;45(1):116848. doi:10.1016/j.celrep.2025.116848
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Tianping Peng, Xiujian Ma, Wei Hua, et al. Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy. Cell Stem Cell. 2025. doi:10.1016/j.stem.2025.01.002
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Sanjima Pal, Elee Shimshoni, Salvador Flores Torres, et al. Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology. Journal of Translational Medicine. 2025;23(1):577. doi:10.1186/s12967-025-06593-1
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Gat Rauner, Piyush B. Gupta, Charlotte Kuperwasser. From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research. Nature Methods. 2025:1-12. doi:10.1038/s41592-025-02769-1
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Yufei Wang, Limin Zhang, Louis Zizhao Wang, et al. The application of organoids in treatment decision-making for digestive system cancers: progress and challenges. Molecular Cancer. 2025;24(1):222. doi:10.1186/s12943-025-02429-0
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Mustafa Sibai, Sergi Cervilla, Daniela Grases, et al. The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity. Cell Reports. 2025;44(2). doi:10.1016/j.celrep.2024.115229
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Jihao Xu, Minh Duc Pham, Vincenzo Corbo, et al. Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology. Experimental & Molecular Medicine. 2025:1-9. doi:10.1038/s12276-024-01378-w
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