Translation and validation

Julia M. L. Menon, Merel Ritskes-Hoitinga, Pandora Pound, Erica van Oort. The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PloS One. 2021;16(12):e0260619. doi:10.1371/journal.pone.0260619

Dean G. Brown, Heike J. Wobst, Abhijeet Kapoor, Leslie A. Kenna, Noel Southall. Clinical development times for innovative drugs. Nature Reviews Drug Discovery. 2021;21(11):793-794. doi:10.1038/d41573-021-00190-9

Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, et al. Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Scientific Reports. 2021;11(1):6403. doi:10.1038/s41598-021-85708-2

Biotechnology Innovation Organization, Informa Pharma Intelligence, Quantitative Life Sciences. Clinical Development Success Rates and Contributing Factors 2011-2020.; 2021:34. https://go.bio.org/rs/490-EHZ-999/images/ClinicalDevelopmentSuccessRates2011_2020.pdf.

Michael Balls. It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question. Alternatives to Laboratory Animals. 2021;49(5):182-196. doi:10.1177/02611929211062223

Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Wouter P. C. Boon, et al. Tradition, not science, is the basis of animal model selection in translational and applied research. ALTEX. 2021;38(1):49-62. doi:10.14573/altex.2003301

Simon Lohse. Scientific inertia in animal-based research in biomedicine. Studies in History and Philosophy of Science Part A. 2021;89:41-51. doi:10.1016/j.shpsa.2021.06.016

Antje Schmidt-Pogoda, Nadine Bonberg, Mailin Hannah Marie Koecke, et al. Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents. Annals of Neurology. 2020;87(1):40-51. doi:10.1002/ana.25643

Pandora Pound, Merel Ritskes-Hoitinga. Can prospective systematic reviews of animal studies improve clinical translation? Journal of Translational Medicine. 2020;18:15. doi:10.1186/s12967-019-02205-x

Pandora Pound. Are Animal Models Needed to Discover, Develop and Test Pharmaceutical Drugs for Humans in the 21st Century? Animals (Basel). 2020;10(12):2455. doi:10.3390/ani10122455