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Translation and validation
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Michael M. Webster, Christian Rutz. How STRANGE are your study animals? Nature. 2020;582:337-340. doi:10.1038/d41586-020-01751-5
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Donald E. Ingber. Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? Advanced Science. 2020;7(22):2002030. doi:10.1002/advs.202002030
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Merel Ritskes-Hoitinga, Cathalijn Leenaars, Wouter Beumer, Tineke Coenen-de Roo, Frans Stafleu, Franck L. B. Meijboom. Improving Translation by Identifying Evidence for More Human-Relevant Preclinical Strategies. Animals: an open access journal from MDPI. 2020;10(7):1170. doi:10.3390/ani10071170
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Antje Schmidt-Pogoda, Nadine Bonberg, Mailin Hannah Marie Koecke, et al. Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents. Annals of Neurology. 2020;87(1):40-51. doi:10.1002/ana.25643
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Pandora Pound, Merel Ritskes-Hoitinga. Can prospective systematic reviews of animal studies improve clinical translation? Journal of Translational Medicine. 2020;18:15. doi:10.1186/s12967-019-02205-x
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Stanley T. Parish, Michael Aschner, Warren Casey, et al. An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Regulatory Toxicology and Pharmacology. 2020;112:104592. doi:10.1016/j.yrtph.2020.104592
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Pandora Pound. Are Animal Models Needed to Discover, Develop and Test Pharmaceutical Drugs for Humans in the 21st Century? Animals (Basel). 2020;10(12):2455. doi:10.3390/ani10122455
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Olivier J. Wouters, Martin McKee, Jeroen Luyten. Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018. JAMA. 2020;323(9):844-853. doi:10.1001/jama.2020.1166
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Jarrod Bailey, Michael Balls. Clinical impact of high-profile animal-based research reported in the UK national press. BMJ Open Science. 2020;4(1):e100039. doi:10.1136/bmjos-2019-100039