Translation and validation

Tracy D. Zhang, Scott C. Kolbe, Leah C. Beauchamp, Ella K. Woodbridge, David I. Finkelstein, Emma L. Burrows. How Well Do Rodent Models of Parkinson’s Disease Recapitulate Early Non-Motor Phenotypes? A Systematic Review. Biomedicines. 2022;10(12):3026. doi:10.3390/biomedicines10123026

Laura Gribaldo, Adelaide Dura. EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders. Animals (Basel). 2022;12(17):2180. doi:10.3390/ani12172180

Jessica Cait, Alissa Cait, R. Wilder Scott, Charlotte B. Winder, Georgia J. Mason. Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis. BMC Biology. 2022;20(1):15. doi:10.1186/s12915-021-01184-0

Lorenzo Del Pace, Laura Viviani, Marco Straccia. Researchers and Their Experimental Models: A Pilot Survey in the Context of the European Union Health and Life Science Research. Animals. 2022;12(20):2778. doi:10.3390/ani12202778

Merel Ritskes-Hoitinga, Pandora Pound. The role of systematic reviews in identifying the limitations of preclinical animal research, 2000-2022: part 1. Journal of the Royal Society of Medicine. 2022;115(5):186-192. doi:10.1177/01410768221093551

Mathias Busek, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Ludivine Delon, Stefan Krauss. Academic User View: Organ-on-a-Chip Technology. Biosensors. 2022;12(2):126. doi:10.3390/bios12020126

Duxin Sun, Wei Gao, Hongxiang Hu, Simon Zhou. Why 90% of clinical drug development fails and how to improve it? Acta Pharmaceutica Sinica B. 2022;12(7):3049-3062. doi:10.1016/j.apsb.2022.02.002

Michael Balls. It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question. Alternatives to Laboratory Animals. 2021;49(5):182-196. doi:10.1177/02611929211062223

Simon Lohse. Scientific inertia in animal-based research in biomedicine. Studies in History and Philosophy of Science Part A. 2021;89:41-51. doi:10.1016/j.shpsa.2021.06.016

Biotechnology Innovation Organization, Informa Pharma Intelligence, Quantitative Life Sciences. Clinical Development Success Rates and Contributing Factors 2011-2020.; 2021:34. https://go.bio.org/rs/490-EHZ-999/images/ClinicalDevelopmentSuccessRates2011_2020.pdf.