Toxicology

Jacob D. Larson, Sushma Jadalannagari, Jake Chaff, et al. Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip. Scientific Reports. 2025;15(1):28132. doi:10.1038/s41598-025-12846-2

K. Taylor, R. Ram, L. Ewart, et al. Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Frontiers in Drug Discovery. 2025;5. doi:10.3389/fddsv.2025.1536756

Eike Cöllen, Kristina Bartmann, Jonathan Blum, et al. Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing. ALTEX - Alternatives to animal experimentation. 2025. doi:10.14573/altex.2501091

Monica Piergiovanni, Milena Mennecozzi, Erio Barale-Thomas, et al. Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology. Archives of Toxicology. 2025. doi:10.1007/s00204-024-03922-z

Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, et al. Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1528748

Andrew S. Robertson, Nahid Latif, Imein Bousnina, et al. Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective. Nature Reviews Drug Discovery. 2025. doi:10.1038/d41573-025-00038-6

Shivangi Shrimali, Minjun Chen, Dongying Li, Weida Tong. New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?. Drug Discovery Today. 2025:104452. doi:10.1016/j.drudis.2025.104452

Xiaozhong Huang, Yun Ting Soong, Jiahao Wang, et al. HIVIL: A human <i>in vitro</i> inflammatory liver model recapitulates immune-associated drug effects with high predictivity. NAM Journal. 2025;1:100032. doi:10.1016/j.namjnl.2025.100032

Robert M. Geiger, Shekh M. Rahman, Md Shadiqur Rashid Roni, et al. Assessment of drug permeability using a small airway microphysiological system. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1621775

Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin. New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches. Toxics. 2025;13(8):693. doi:10.3390/toxics13080693