Reviews and perspectives

Zehra Yildirim, Kyle Swanson, Xuekun Wu, James Zou, Joseph Wu. Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish. Annual Review of Pharmacology and Toxicology. 2025;65(Volume 65, 2025):71-90. doi:10.1146/annurev-pharmtox-022724-095035

Tina Woods, Nic Palmarini, Lynne Corner, et al. Cities, communities and clinics can be testbeds for human exposome and aging research. Nature Medicine. 2025:1-3. doi:10.1038/s41591-025-03519-8

AM Anu Varshini, Usha Nandini S, V Ramesh Kumar, Thangam T, Krupakar Parthasarathy. New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model. NAM Journal. 2025;1:100003. doi:10.1016/j.namjnl.2024.100003

Saif F. Dababneh, Hosna Babini, Verónica Jiménez-Sábado, Sheila S. Teves, Kyoung-Han Kim, Glen F. Tibbits. Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models. Stem Cell Reports. 2025;20(4). doi:10.1016/j.stemcr.2025.102467

Uwe Marx, Sonja Beken, Zaozao Chen, et al. Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare. ALTEX - Alternatives to animal experimentation. 2025;42(2):204-223. doi:10.14573/altex.2410112

Thomas Hartung, Lena Smirnova. A path forward advancing microphysiological systems. ALTEX - Alternatives to animal experimentation. 2025;42(2):183-203. doi:10.14573/altex.2504091

Ronin-Mae Komarnisky, Shaun Wootten, Nathan Friedman, Mehdi Nikkhah. Organ-on-a-chip: key industry insights, challenges, and opportunities from 100+ NSF I-Corps interviews. Lab on a Chip. 2025. doi:10.1039/D5LC00426H

Mathieu Vinken, Daniela Grimm, Sarah Baatout, et al. Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research. Biotechnology Advances. 2025;81:108574. doi:10.1016/j.biotechadv.2025.108574

Francesca Pistollato, Fabia Furtmann, Sarah Abitbol, et al. Leveraging innovative research tools to meet public health challenges: a BioMed21 workshop report. NAM Journal. 2025;1:100023. doi:10.1016/j.namjnl.2025.100023

Daisong Wang, Remi Villenave, Nadine Stokar-Regenscheit, Hans Clevers. Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges. Nature Reviews Drug Discovery. 2025:1-23. doi:10.1038/s41573-025-01317-y