Nervous system

Sara Guerreiro, Patrícia Maciel. Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges. Cells. 2023;12(4):538. doi:10.3390/cells12040538

Rebecca J. Levy, Sergiu P. Pașca. What Have Organoids and Assembloids Taught Us About the Pathophysiology of Neuropsychiatric Disorders? Biological Psychiatry. 2023;93(7):632-641. doi:10.1016/j.biopsych.2022.11.017

Allison L. Ludwig, Steven J. Mayerl, Yu Gao, et al. Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures. Proceedings of the National Academy of Sciences. 2023;120(2):e2213418120. doi:10.1073/pnas.2213418120

Luciana Simões Rafagnin Marinho, Gabrielly Maria Denadai Chiarantin, Juliane Midori Ikebara, et al. The impact of antidepressants on human neurodevelopment: Brain organoids as experimental tools. Seminars in Cell & Developmental Biology. 2023;144:67-76. doi:10.1016/j.semcdb.2022.09.007

Chong Li, Jonas Simon Fleck, Catarina Martins-Costa, et al. Single-cell brain organoid screening identifies developmental defects in autism. Nature. 2023;621(7978):373-380. doi:10.1038/s41586-023-06473-y

Jonas Simon Fleck, Sophie Martina Johanna Jansen, Damian Wollny, et al. Inferring and perturbing cell fate regulomes in human brain organoids. Nature. 2023;621(7978):365-372. doi:10.1038/s41586-022-05279-8

Philipp Wahle, Giovanna Brancati, Christoph Harmel, et al. Multimodal spatiotemporal phenotyping of human retinal organoid development. Nature Biotechnology. 2023. doi:10.1038/s41587-023-01747-2

Chiara Dionisi, Marine Chazalon, Myriam Rai, et al. Proprioceptors-enriched neuronal cultures from induced pluripotent stem cells from Friedreich ataxia patients show altered transcriptomic and proteomic profiles, abnormal neurite extension, and impaired electrophysiological properties. Brain Communications. 2023;5(1):fcad007. doi:10.1093/braincomms/fcad007

Isabel Rosety, Alise Zagare, Claudia Saraiva, et al. Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids. npj Parkinson’s Disease. 2023;9:166. doi:10.1038/s41531-023-00616-8

Daniel Reumann, Christian Krauditsch, Maria Novatchkova, et al. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids. Nature Methods. 2023;20:2034-2047. doi:10.1038/s41592-023-02080-x