Nervous system

Kyubin Seo, Subin Cho, Hyogeun Shin, et al. Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization. Advanced Science. 2023;10(20):2301787. doi:10.1002/advs.202301787

Rebecca J. Levy, Sergiu P. Pașca. What Have Organoids and Assembloids Taught Us About the Pathophysiology of Neuropsychiatric Disorders?. Biological Psychiatry. 2023;93(7):632-641. doi:10.1016/j.biopsych.2022.11.017

János M. Réthelyi, Katalin Vincze, Dorothea Schall, Jeffrey Glennon, Simone Berkel. The role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders – Evidence from human neuronal cell models. Neuroscience & Biobehavioral Reviews. 2023;153:105330. doi:10.1016/j.neubiorev.2023.105330

Allison L. Ludwig, Steven J. Mayerl, Yu Gao, et al. Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures. Proceedings of the National Academy of Sciences. 2023;120(2):e2213418120. doi:10.1073/pnas.2213418120

Summer R. Fair, Wesley Schwind, Dominic L. Julian, et al. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain: A Journal of Neurology. 2023;146(1):387-404. doi:10.1093/brain/awac244

Ayşe J. Muñiz, Tuğba Topal, Michael D. Brooks, et al. Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells. Annals of Clinical and Translational Neurology. 2023;10(7):1239-1253. doi:10.1002/acn3.51820

Yogita K. Adlakha. Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. Cell Death Discovery. 2023;9(1):1-17. doi:10.1038/s41420-023-01523-w

Rebecca Sebastian, Kang Jin, Narciso Pavon, et al. Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids. Nature Communications. 2023;14(1):3770. doi:10.1038/s41467-023-39420-6

Luciana Simões Rafagnin Marinho, Gabrielly Maria Denadai Chiarantin, Juliane Midori Ikebara, et al. The impact of antidepressants on human neurodevelopment: Brain organoids as experimental tools. Seminars in Cell & Developmental Biology. 2023;144:67-76. doi:10.1016/j.semcdb.2022.09.007

Isabel Rosety, Alise Zagare, Claudia Saraiva, et al. Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids. npj Parkinson’s Disease. 2023;9:166. doi:10.1038/s41531-023-00616-8