Nervous system

Xianwei Chen, Guoqiang Sun, Lizhao Feng, E. Tian, Yanhong Shi. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids. Communications Biology. 2025;8(1):1-11. doi:10.1038/s42003-024-07401-0

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Dana M. Cairns, Brooke M. Smiley, Jordan A. Smiley, et al. Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model. Science Signaling. 2025;18(868):eado6430. doi:10.1126/scisignal.ado6430

Wendy Balestri, Ruchi Sharma, Victor A. da Silva, et al. Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases. Journal of Neuroinflammation. 2024;21(1):32. doi:10.1186/s12974-024-03024-8

Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024;628:391-399. doi:10.1038/s41586-024-07204-7

Nadav Yayon, Veronika R. Kedlian, Lena Boehme, et al. A spatial human thymus cell atlas mapped to a continuous tissue axis. Nature. 2024;635(8039):708-718. doi:10.1038/s41586-024-07944-6

Christina Steyn, Ruvimbo Mishi, Stephanie Fillmore, et al. A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation. Nature Genetics. 2024:1-13. doi:10.1038/s41588-024-01990-6

Zhisong He, Leander Dony, Jonas Simon Fleck, et al. An integrated transcriptomic cell atlas of human neural organoids. Nature. 2024;635(8039):690-698. doi:10.1038/s41586-024-08172-8

Nicolas Boulant, Franck Mauconduit, Vincent Gras, et al. In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner. Nature Methods. 2024;21(11):2013-2016. doi:10.1038/s41592-024-02472-7

Francesca Fagiani, Edoardo Pedrini, Stefano Taverna, et al. A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis. Cell Reports Medicine. 2024:101680. doi:10.1016/j.xcrm.2024.101680