Nervous system

Boning Qiu, Sara Pompe, Katerina T. Xenaki, et al. Generation of a perfusable three-dimensional human neurovascular chip to model brain drug delivery and immune cell extravasation. Journal of Controlled Release. 2025;387:114257. doi:10.1016/j.jconrel.2025.114257

James G. Shamul, Zhiyuan Wang, Hyeyeon Gong, et al. Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier. Nature Biomedical Engineering. 2025;9(4):566-598. doi:10.1038/s41551-024-01250-2

Judit González-Gallego, Katalin Todorov-Völgyi, Stephan A. Müller, et al. A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. Nature Neuroscience. 2025:1-14. doi:10.1038/s41593-025-02123-w

Isabel Turpin-Moreno, Adriana Modrego, Andrea Martí-Sarrias, et al. Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning. iScience. 2025;28(11). doi:10.1016/j.isci.2025.113831

Chunhui Tian, Zheng Ao, Jonas Cerneckis, et al. Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems. Science Advances. 2025;11(34):eadu2708. doi:10.1126/sciadv.adu2708

Simona Lange, Martin Ebeling, Athéna Loye, et al. Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies. Science Translational Medicine. 2025;17(815):eadp7047. doi:10.1126/scitranslmed.adp7047

Carlos Serna, Bhavya Bhardwaj, Tromondae K. Feaster, Ksenia Blinova. Nonclinical human neural new approach methodologies (NAMs): Electrophysiological assessment of opioid agonist and antagonist combination. NAM Journal. 2025;1:100064. doi:10.1016/j.namjnl.2025.100064

Adrià Casamitjana, Matteo Mancini, Eleanor Robinson, et al. A probabilistic histological atlas of the human brain for MRI segmentation. Nature. 2025:1-8. doi:10.1038/s41586-025-09708-2

Irene Faravelli, Noelia Antón-Bolaños, Juliana R. Brown, Paola Arlotta. Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain. Annual Review of Genomics and Human Genetics. 2025;26(Volume 26, 2025):299-320. doi:10.1146/annurev-genom-111522-014009

Christopher R. Bye, Elizabeth Qian, Katherine Lim, et al. Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. Nature Neuroscience. 2025:1-13. doi:10.1038/s41593-025-02118-7