Immune/infectious disease

Keitaro Kanie, Takeshi Ito, Genzo Iguchi, et al. Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid. Nature Communications. 2025;16(1):7900. doi:10.1038/s41467-025-63183-x

Xin Chen, Mustafa Ghanizada, Vamsee Mallajosyula, et al. Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. Nature Immunology. 2025:1-10. doi:10.1038/s41590-024-02062-x

Titilola D. Kalejaiye, Rohan Bhattacharya, Samira Musah. A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation. Cellular and Molecular Bioengineering. 2025. doi:10.1007/s12195-025-00851-4

Angelica Medina, Yu-Chi Chen, Jiajing Zhang, et al. Modeling neurotropic virus infection with functional human neural spheroids as a platform for high-throughput antiviral screening and pathogenesis. Antiviral Research. 2025;242:106248. doi:10.1016/j.antiviral.2025.106248

Yuncheng Man, Ryan R. Posey, Haiqing Bai, et al. Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip. Lab on a Chip. 2025. doi:10.1039/D5LC00156K

Zhe Zhong, Manuel Quiñones-Pérez, Zhonghao Dai, et al. Human immune organoids to decode B cell response in healthy donors and patients with lymphoma. Nature Materials. 2024:1-15. doi:10.1038/s41563-024-02037-1

Arkadiusz Pierzchalski, Ana C. Zenclussen, Gunda Herberth. A comprehensive battery of flow cytometric immunoassays for the in vitro testing of chemical effects in human blood cells. Frontiers in Immunology. 2024;14. doi:10.3389/fimmu.2023.1327960

Cun Li, Yifei Yu, Zhixin Wan, et al. Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction. Nature Communications. 2024;15(1):10772. doi:10.1038/s41467-024-55076-2

Abigail J. Clevenger, Aakanksha Jha, Erika Moore, Shreya A. Raghavan. Manipulating immune activity of macrophages: a materials and mechanics perspective. Trends in Biotechnology. 2024. doi:10.1016/j.tibtech.2024.07.009

James Nyirenda, Olympia M. Hardy, João Da Silva Filho, et al. Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population. Nature Medicine. 2024:1-13. doi:10.1038/s41591-024-03354-3