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Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019
ReferenceEkaterina Galkina Cleary , Matthew J. Jackson , Edward W. Zhou , Fred D. Ledley JAMA Health Forum. 2023;4(4):e230511. doi: 10.1001/jamahealthforum.2023.0511 Government and the pharmaceutical industry make substantive contributions to pharmaceutical …
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss
ReferenceLaura Rüland , Francesco Andreatta , Simone Massalini , Susana Chuva de Sousa Lopes , Hans Clevers , Delilah Hendriks , Benedetta Artegiani Nature Communications. 2023;14(1):2377. doi: 10.1038/s41467-023-37951-6 Fibrolamellar carcinoma (FLC) is a lethal …
Impact of organ-on-a-chip technology on pharmaceutical R&D costs
ReferenceNora Franzen , Wim H. van Harten , Valesca P. Retèl , Peter Loskill , Janny van den Eijnden-van Raaij , Maarten IJzerman Drug Discovery Today. 2019;24(9):1720-1724. doi: 10.1016/j.drudis.2019.06.003 Healthcare systems are faced with the challenge of …
Academic User View: Organ-on-a-Chip Technology
ReferenceMathias Busek , Aleksandra Aizenshtadt , Mikel Amirola-Martinez , Ludivine Delon , Stefan Krauss Biosensors. 2022;12(2):126. doi: 10.3390/bios12020126 Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for …
The role of systematic reviews in identifying the limitations of preclinical animal research, 2000-2022: part 2
ReferenceMerel Ritskes-Hoitinga , Pandora Pound Journal of the Royal Society of Medicine. 2022;115(6):231-235. doi: 10.1177/01410768221100970 Keywords animal experimentation Animals Humans Research Design Systematic Reviews as Topic Download Citation BibTeX …
Animal Research for Alzheimer Disease: Failures of Science and Ethics
ReferenceJohn J. Pippin , Sarah E. Cavanaugh , Francesca Pistollato , Kathrin Herrmann , Kimberley Jayne Animal Experimentation: Working Towards a Paradigm Change. Brill; 2019:480-516. Perhaps the most impactful and foreboding development in chronic diseases in …
Afterword: Evidence over Interests
ReferenceJohn P. Gluck , Kathrin Herrmann , Kimberley Jayne Animal Experimentation. Brill; 2019:689-691. After years of science education, teaching experience, and research practice, which focused on the use of non-human primates as potential models of human …
The Decision-Making Constraints and Processes of Grant Peer Review, and Their Effects on the Review Outcome
ReferenceLiv Langfeldt , Eva Forsberg , Lars Geschwind , Sara Levander , Wieland Wermke Peer review in an Era of Evaluation. London: Palgrave Macmillan Cham; 2022:297-326. When distributing grants, research councils use peer expertise as a guarantee for supporting …
Standards for Initiating a Systematic Review
ReferenceInstitute of Medicine (US) Committee on Standards for Systematic Reviews of Comparative Effectiveness Research , Jill Eden , Laura Levit , Alfred Berg , Sally Morton Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: …
Arguments Against Using Nonhuman Primates in Research
ReferenceJarrod Bailey , Lauren M. Robinson , Alexander Weiss Nonhuman Primate Welfare: From History, Science, and Ethics to Practice. Cham: Springer International Publishing; 2023:559-588. Most people oppose using nonhuman primates for research from an ethical …