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Animal-free alternatives and the antibody iceberg
ReferenceAlison Gray , Andrew R. M. Bradbury , Achim Knappik , Andreas Plückthun , Carl A. K. Borrebaeck , Stefan Dübel Nature Biotechnology. 2020;38(11):1234-1239. doi: 10.1038/s41587-020-0687-9 https://www.nature.com/articles/s41587-020-0687-9 Keywords …
Reproducibility: Standardize antibodies used in research
ReferenceAndrew Bradbury , Andreas Plückthun Nature. 2015;518(7537):27-29. doi: 10.1038/518027a To save millions of dollars and dramatically improve reproducibility, protein-binding reagents must be defined by their sequences and produced as recombinant proteins, …
Animal-Friendly Affinity Reagents: Replacing the Needless in the Haystack
ReferenceA. C. Gray , S. S. Sidhu , P. C. Chandrasekera , C. F. M. Hendriksen , C. a. K. Borrebaeck Trends in Biotechnology. 2016;34(12):960-969. doi: 10.1016/j.tibtech.2016.05.017 https://www.cell.com/trends/biotechnology/abstract/S0167-7799(16)30063-4 Keywords …
Reproducibility crisis: Blame it on the antibodies
ReferenceMonya Baker Nature. 2015;521(7552):274-276. doi: 10.1038/521274a Antibodies are the workhorses of biological experiments, but they are littering the field with false findings. A few evangelists are pushing for change. …
A proposal for validation of antibodies
ReferenceMathias Uhlen , Anita Bandrowski , Steven Carr , Aled Edwards , Jan Ellenberg , Emma Lundberg , David L. Rimm , Henry Rodriguez , Tara Hiltke , Michael Snyder , Tadashi Yamamoto Nature Methods. 2016;13(10):823-827. doi: 10.1038/nmeth.3995 We convened an …
A standardised framework to identify optimal animal models for efficacy assessment in drug development
ReferenceGuilherme S. Ferreira , Désirée H. Veening-Griffioen , Wouter P. C. Boon , Ellen H. M. Moors , Christine C. Gispen-de Wied , Huub Schellekens , Peter J. K. Van Meer PLOS ONE. ;14(6):e0218014. doi: 10.1371/journal.pone.0218014 Introduction Poor translation …
Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments
ReferenceCristina QuĂlez , LuĂs B. Bebiano , Eleri Jones , Uroš Maver , Luca Meesters , Piotr Parzymies , Emma Petiot , Gijs Rikken , Ignacio Risueño , Hamza Zaidi , Tanja ZidariÄŤ , Sander Bekeschus , Ellen H. van den Bogaard , Matthew Caley , Helen Colley , Nuria …
Harvesting the promise of AOPs: An assessment and recommendations
ReferenceAnnamaria Carusi , Mark R. Davies , Giovanni De Grandis , Beate I. Escher , Geoff Hodges , Kenneth M. Y. Leung , Maurice Whelan , Catherine Willett , Gerald T. Ankley The Science of the Total Environment. 2018;628-629:1542-1556. doi: …
Expertise versus Bias in Evaluation: Evidence from the NIH
ReferenceDanielle Li American Economic Journal: Applied Economics. 2017;9(2):60-92. doi: 10.1257/app.20150421 Evaluators with expertise in a particular field may have an informational advantage in separating good projects from bad. At the same time, they may also …
What should be rewarded? Gender and evaluation criteria for tenure and promotion
ReferenceLaura Cruz-Castro , Luis Sanz-Menendez Journal of Informetrics. 2021;15(3):101196. doi: 10.1016/j.joi.2021.101196 Criteria for assessing candidates are essential elements for the functioning of evaluation practices in academia. This article addresses a …