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Animal researchers shoulder a psychological burden that animal ethics committees ought to address
ReferenceMike King , Hazem Zohny Journal of Medical Ethics. 2022;48(5):299-303. doi: 10.1136/medethics-2020-106945 Animal ethics committees (AECs) typically focus on the welfare of animals used in experiments, neglecting the potential welfare impact of that animal …
Laboratory Animal Welfare Meets Human Welfare: A Cross-Sectional Study of Professional Quality of Life, Including Compassion Fatigue in Laboratory Animal Personnel
ReferenceMegan R. LaFollette , Megan C. Riley , Sylvie Cloutier , Colleen M. Brady , Marguerite E. O'Haire , Brianna N. Gaskill Frontiers in Veterinary Science. 2020;7. doi: 10.3389/fvets.2020.00114 Laboratory animal personnel may experience significant stress …
Journals must expand access to peer review data
ReferenceOlivia M. Smith , Kayla L. Davis , Robin Waterman , Riley B. Pizza , Caitlin Mack , Emily E. Conway , Kara C. Dobson , Brianna Foster , Ani E. Hristova , Julie C. Jarvey , Nan Nourn , Courtney L. Davis Trends in Ecology & Evolution. 2024;39(4):311-314. …
Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism
ReferenceKatharina Schlünder , Madalena Cipriano , Aline Zbinden , Stefanie Fuchs , Torsten Mayr , Katja Schenke-Layland , Peter Loskill Lab on a Chip. 2024. doi: 10.1039/D3LC00838J Pancreatic in vitro research is of major importance to advance mechanistic …
Towards a better understanding of diabetes mellitus using organoid models
ReferenceBelin Selcen Beydag-Tasöz , Siham Yennek , Anne Grapin-Botton Nature Reviews Endocrinology. 2023;19(4):232-248. doi: 10.1038/s41574-022-00797-x Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in …
Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research
ReferenceBelén Casas , Liisa Vilén , Sophie Bauer , Kajsa P. Kanebratt , Charlotte Wennberg Huldt , Lisa Magnusson , Uwe Marx , Tommy B. Andersson , Peter Gennemark , Gunnar Cedersund PLOS Computational Biology. ;18(10):e1010587. doi: 10.1371/journal.pcbi.1010587 …
Microphysiological Analysis Platform of Pancreatic Islet β-Cell Spheroids
ReferenceSang Hun Lee , SoonGweon Hong , Jihwan Song , Byungrae Cho , Esther J. Han , Sravani Kondapavulur , Dongchoul Kim , Luke P. Lee Advanced Healthcare Materials. 2018;7(2). doi: 10.1002/adhm.201701111 The hallmarks of diabetics are insufficient secretion of …
In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids
ReferenceYesl Jun , JaeSeo Lee , Seongkyun Choi , Ji Hun Yang , Maike Sander , Seok Chung , Sang-Hoon Lee Science Advances. 2019;5(11):eaax4520. doi: 10.1126/sciadv.aax4520 Native pancreatic islets interact with neighboring cells by establishing three-dimensional …
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
ReferenceSophie Bauer , Charlotte Wennberg Huldt , Kajsa P. Kanebratt , Isabell Durieux , Daniela Gunne , Shalini Andersson , Lorna Ewart , William G. Haynes , Ilka Maschmeyer , Annika Winter , Carina Ämmälä , Uwe Marx , Tommy B. Andersson Scientific Reports. …
In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution
ReferencePatrick M. Misun , Burçak Yesildag , Felix Forschler , Aparna Neelakandhan , Nassim Rousset , Adelinn Biernath , Andreas Hierlemann , Olivier Frey Advanced Biosystems. 2020;4(3):e1900291. doi: 10.1002/adbi.201900291 Insulin is released from pancreatic …