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Organoid Modeling of the Tumor Immune Microenvironment
ReferenceJames T. Neal , Xingnan Li , Junjie Zhu , Valeria Giangarra , Caitlin L. Grzeskowiak , Jihang Ju , Iris H. Liu , Shin-Heng Chiou , Ameen A. Salahudeen , Amber R. Smith , Brian C. Deutsch , Lillian Liao , Allison J. Zemek , Fan Zhao , Kasper Karlsson , …
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
ReferenceAmeen A. Salahudeen , Shannon S. Choi , Arjun Rustagi , Junjie Zhu , Vincent van Unen , Sean M. de la O , Ryan A. Flynn , Mar Margalef-Català , António J. M. Santos , Jihang Ju , Arpit Batish , Tatsuya Usui , Grace X. Y. Zheng , Caitlin E. Edwards , Lisa …
Training the Next Generation of Researchers in the Organ-on-Chip Field
ReferenceAlessia Moruzzi , Tanvi Shroff , Silke Keller , Peter Loskill , Madalena Cipriano Education Sciences. 2023;13(2):144. doi: 10.3390/educsci13020144 Organ-on-chip (OoC) technology bridges the principles of biology and engineering to create a new generation …
Neurotrophins and Their Receptors, Novel Therapeutic Targets for Pelvic Pain in Endometriosis, Are Coordinately Regulated by IL-1β via the JNK Signaling Pathway
ReferenceJie Yu , Sarah L. Berga , Eric Zou , Andrew D. Schrepf , Daniel J. Clauw , Sawsan As-Sanie , Robert N. Taylor The American Journal of Pathology. 2023;193(8):1046-1058. doi: 10.1016/j.ajpath.2023.04.007 …
Progress and opportunities for tissue-engineered skin
ReferenceSheila MacNeil Nature. 2007;445(7130):874-880. doi: 10.1038/nature05664 Tissue-engineered skin is now a reality. For patients with extensive full-thickness burns, laboratory expansion of skin cells to achieve barrier function can make the difference …
Pump-less, recirculating organ-on-a-chip (rOoC) platform
ReferenceMathias Busek , Aleksandra Aizenshtadt , Timo Koch , Anna Frank , Ludivine Delon , Mikel Amirola Martinez , Alexey Golovin , Clotilde Dumas , Justyna Stokowiec , Stefan Gruenzner , Espen Melum , Stefan Krauss Lab on a Chip. 2023;23(4):591-608. doi: …
The Application of Organs-on-a-Chip in Dental, Oral, and Craniofacial Research
ReferenceC. Huang , F. Sanaei , W.P.R. Verdurmen , F. Yang , W. Ji , X. F. Walboomers Journal of Dental Research. 2023;102(4):364-375. doi: 10.1177/00220345221145555 The current development of microfluidics-based microphysiological systems (MPSs) will rapidly lead …
Advancing nonclinical innovation and safety in pharmaceutical testing
ReferenceElizabeth J. Baker , Nancy A. Beck , Ellen L. Berg , Helene D. Clayton-Jeter , P. Charukeshi Chandrasekera , J. Lowry Curley , Bruce A. Donzanti , Lorna C. Ewart , Jane M. Gunther , J. Gerry Kenna , Edward L. LeCluyse , Michael N. Liebman , Catherine L. …
Tumor organoid biobank-new platform for medical research
ReferenceXuexue Xie , Xinyu Li , Wei Song Scientific Reports. 2023;13(1):1819. doi: 10.1038/s41598-023-29065-2 Organoids are a new type of 3D model for tumor research, which makes up for the shortcomings of cell lines and xenograft models, and promotes the …
Policy driven changes in animal research practices: mapping researchers’ attitudes towards animal-free innovations using the Netherlands as an example
ReferenceSteffi Bressers , Hester van den Elzen , Cathrin Gräwe , Daphne van den Oetelaar , Pieter H. A. Postma , Sybren K. Schoustra Research Integrity and Peer Review. 2019;4:8. doi: 10.1186/s41073-019-0067-5 Reducing the number of animals used in experiments …