Stem-cell biotechnology

John C. Means, Anabel L. Martinez-Bengochea, Daniel A. Louiselle, et al. Rapid and scalable personalized ASO screening in patient-derived organoids. Nature. 2025:1-7. doi:10.1038/s41586-024-08462-1

Yeon-Woo Cho, Min-Ji Kang, Joon-Ha Park, Yun-Sik Eom, Tae-Hyung Kim. Spatially controlled multicellular differentiation of stem cells using triple factor-releasing metal–organic framework-coated nanoline arrays. Nature Communications. 2025;16(1):1389. doi:10.1038/s41467-025-56373-0

Xianwei Chen, Guoqiang Sun, Lizhao Feng, E. Tian, Yanhong Shi. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids. Communications Biology. 2025;8(1):1-11. doi:10.1038/s42003-024-07401-0

Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa, et al. Multi-zonal liver organoids from human pluripotent stem cells. Nature. 2025:1-10. doi:10.1038/s41586-025-08850-1

Ryo Igarashi, Mayumi Oda, Ryo Okada, et al. Generation of human adult hepatocyte organoids with metabolic functions. Nature. 2025:1-10. doi:10.1038/s41586-025-08861-y

Xin Cui, Xinwei Li, Huimin Zheng, et al. Human midbrain organoids: a powerful tool for advanced Parkinson’s disease modeling and therapy exploration. npj Parkinson’s Disease. 2024;10(1):1-14. doi:10.1038/s41531-024-00799-8

Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira. Cellular reprogramming as a tool to model human aging in a dish. Nature Communications. 2024;15(1):1816. doi:10.1038/s41467-024-46004-5

Moritz Hofer, Maria A. Duque-Correa, Matthias P. Lutolf. Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection. Nature Biomedical Engineering. 2024:1-11. doi:10.1038/s41551-024-01313-4

Drew R. Neavin, Angela M. Steinmann, Nona Farbehi, et al. A village in a dish model system for population-scale hiPSC studies. Nature Communications. 2023;14(1):3240. doi:10.1038/s41467-023-38704-1

Kevin G. Chen, Kyeyoon Park, Jason R. Spence. Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids. Nature Cell Biology. 2021;23(8):822-833. doi:10.1038/s41556-021-00721-x