Neurodegeneration

Guido Kroemer, Andrea B. Maier, Ana Maria Cuervo, et al. From geroscience to precision geromedicine: Understanding and managing aging. Cell. 2025;188(8):2043-2062. doi:10.1016/j.cell.2025.03.011

Cristina Dolciotti, Marco Righi, Eleonora Grecu, et al. The translational power of Alzheimer's-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history. Frontiers in Cellular Neuroscience. 2025;19. doi:10.3389/fncel.2025.1553642

Leandro H. Gallo, Nesar Akanda, Kaveena Autar, et al. A functional aged human iPSC-cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics. Alzheimer’s & Dementia. 2024;20(9):5940-5960. doi:10.1002/alz.14044

Alberto Granzotto, Bryce Vissel, Stefano L Sensi. Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research. Timothy E Behrens, ed. eLife. 2024;13:e90633. doi:10.7554/eLife.90633

Sarah Spitz, Eunkyung Ko, Peter Ertl, Roger D. Kamm. How Organ-on-a-Chip Technology Can Assist in Studying the Role of the Glymphatic System in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2023;24(3):2171. doi:10.3390/ijms24032171

Terry C. Burns, Matthew D. Li, Swapnil Mehta, Ahmed J. Awad, Alexander A. Morgan. Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models. European Journal of Pharmacology. 2015;759:101-117. doi:10.1016/j.ejphar.2015.03.021