Humans

Kathy Archibald, Katya Tsaioun, J. Gerry Kenna, Pandora Pound. Better science for safer medicines: the human imperative. Journal of the Royal Society of Medicine. 2018;111(12):433-438. doi:10.1177/0141076818812783

Jarno Drost, Hans Clevers. Organoids in cancer research. Nature Reviews. Cancer. 2018;18(7):407-418. doi:10.1038/s41568-018-0007-6

Norman Sachs, Joep de Ligt, Oded Kopper, et al. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 2018;172(1-2):373-386.e10. doi:10.1016/j.cell.2017.11.010

James T. Neal, Xingnan Li, Junjie Zhu, et al. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 2018;175(7):1972-1988.e16. doi:10.1016/j.cell.2018.11.021

Kacey Ronaldson-Bouchard, Gordana Vunjak-Novakovic. Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. Cell Stem Cell. 2018;22(3):310-324. doi:10.1016/j.stem.2018.02.011

Jarrod Bailey, Shiranee Pereira. Advances in neuroscience imply that harmful experiments in dogs are unethical. Journal of Medical Ethics. 2018;44(1):47-52. doi:10.1136/medethics-2016-103630

Janet Piñero, Laura I. Furlong, Ferran Sanz. In silico models in drug development: where we are. Current Opinion in Pharmacology. 2018;42:111-121. doi:10.1016/j.coph.2018.08.007

Sang Hun Lee, SoonGweon Hong, Jihwan Song, et al. Microphysiological Analysis Platform of Pancreatic Islet β-Cell Spheroids. Advanced Healthcare Materials. 2018;7(2). doi:10.1002/adhm.201701111

Dorothée Diogo, Chao Tian, Christopher S. Franklin, et al. Phenome-wide association studies across large population cohorts support drug target validation. Nature Communications. 2018;9(1):4285. doi:10.1038/s41467-018-06540-3

Catherine C. Bell, Anita C. A. Dankers, Volker M. Lauschke, et al. Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. Toxicological Sciences: An Official Journal of the Society of Toxicology. 2018;162(2):655-666. doi:10.1093/toxsci/kfx289