Stem-cell differentiation

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Holly M. Poling, Théo Noël, Akaljot Singh, et al. Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement. Nature Biomedical Engineering. 2026:1-17. doi:10.1038/s41551-026-01688-6
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Ying-Yu Lin, Parker Esswein, Lucas Ramirez, Emily Warren, Julian Nicenboim, Sharon Gerecht. Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling. Nature Biomedical Engineering. 2026:1-22. doi:10.1038/s41551-026-01712-9
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John C. Means, Anabel L. Martinez-Bengochea, Daniel A. Louiselle, et al. Rapid and scalable personalized ASO screening in patient-derived organoids. Nature. 2025:1-7. doi:10.1038/s41586-024-08462-1
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M. Iveth Garcia, Keri Dame, Verena Charwat, et al. Human induced pluripotent stem cell-derived cardiomyocytes and their use in a cardiac organ-on-a-chip to assay electrophysiology, calcium and contractility. Nature Protocols. 2025:1-47. doi:10.1038/s41596-025-01166-4
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Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa, et al. Multi-zonal liver organoids from human pluripotent stem cells. Nature. 2025:1-10. doi:10.1038/s41586-025-08850-1
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Rohan Bhattacharya, Tarsha Ward, Titilola D. Kalejaiye, et al. Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations. Nature Biomedical Engineering. 2025:1-20. doi:10.1038/s41551-025-01543-0
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Judit González-Gallego, Katalin Todorov-Völgyi, Stephan A. Müller, et al. A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. Nature Neuroscience. 2025:1-14. doi:10.1038/s41593-025-02123-w
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