organ-on-chip

Thomas Hartung, Lena Smirnova. A path forward advancing microphysiological systems. ALTEX - Alternatives to animal experimentation. 2025;42(2):183-203. doi:10.14573/altex.2504091

Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, et al. Human-based complex in vitro models: their promise and potential for rare disease therapeutics. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1526306

Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, et al. Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1528748

Amit Gangwal, Antonio Lavecchia. Artificial intelligence in preclinical research: enhancing digital twins and organ-on-chip to reduce animal testing. Drug Discovery Today. 2025;30(5):104360. doi:10.1016/j.drudis.2025.104360

Katharina Stefanie Nitsche, Iris Müller, Sophie Malcomber, Paul Lawford Carmichael, Hans Bouwmeester. Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions. Frontiers in Toxicology. 2025;7. doi:10.3389/ftox.2025.1649393

Andrew I. Morrison, Jonas Jäger, Charlotte M. de Winde, et al. Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties. Materials Today Bio. 2025;35:102326. doi:10.1016/j.mtbio.2025.102326

Dennis M. Nahon, Marc Vila Cuenca, Francijna E. van den Hil, et al. Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes. Stem Cell Reports. 2024;19(7):946-956. doi:10.1016/j.stemcr.2024.05.006

Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, et al. An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells. Cell Reports. 2024;43(7). doi:10.1016/j.celrep.2024.114247

Tengku Ibrahim Maulana, Claudia Teufel, Madalena Cipriano, et al. Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells. Cell Stem Cell. 2024;31(7):989-1002.e9. doi:10.1016/j.stem.2024.04.018

Olga Mitrofanova, Mikhail Nikolaev, Quan Xu, et al. Bioengineered human colon organoids with in vivo-like cellular complexity and function. Cell Stem Cell. 2024;31(8):1175-1186.e7. doi:10.1016/j.stem.2024.05.007