Neurodegenerative Diseases

Chenfeng He, Athan Z. Li, Kalpana Hanthanan Arachchilage, et al. AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data. Nature Medicine. 2026:1-13. doi:10.1038/s41591-025-04128-1

Pramod Bharadwaj Chandrashekar, Sayali Anil Alatkar, Noah Cohen Kalafut, et al. Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease. Nature Communications. 2026;17(1):9596. doi:10.1038/s41467-026-72310-1

Soupayan Banerjee, Pranathi Mirale Chandu, Meghna Sarkar, et al. Engineering brain organoids and organ-on-chip systems for modeling neurodevelopmental and neurodegenerative pathophysiology. Neurological Research. 2025:1-18. doi:10.1080/01616412.2025.2600434

Wendy Balestri, Ruchi Sharma, Victor A. da Silva, et al. Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases. Journal of Neuroinflammation. 2024;21(1):32. doi:10.1186/s12974-024-03024-8

Carla Cuní-López, Romal Stewart, Anthony R. White, Hazel Quek. 3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases. Journal of Neuroimmunology. 2023;375:578017. doi:10.1016/j.jneuroim.2023.578017

Oliver L. Eichmüller, Juergen A. Knoblich. Human cerebral organoids - a new tool for clinical neurology research. Nature Reviews. Neurology. 2022;18(11):661-680. doi:10.1038/s41582-022-00723-9

Eric Vallabh Minikel, Konrad J. Karczewski, Hilary C. Martin, et al. Evaluating drug targets through human loss-of-function genetic variation. Nature. 2020;581(7809):459-464. doi:10.1038/s41586-020-2267-z