microphysiological systems

Patrizia Tornabene, Estelle Berreur, Adrian Roth, Magdalena Kasendra. Microphysiological systems to accelerate and de-risk AAV gene therapy development. Advanced Drug Delivery Reviews. 2026;233:115841. doi:10.1016/j.addr.2026.115841

Nilanjan Roy, Luca Cucullo. Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation. Biosensors. 2026;16(3). doi:10.3390/bios16030155

Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler. Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips. Advanced Biology. 2026;10(2):e00536. doi:10.1002/adbi.202500536

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Chao Song, Jiachen Yang, Zhongze Gu. Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review. Ageing Research Reviews. 2025;107:102728. doi:10.1016/j.arr.2025.102728

Snehal Raut, Aditya Bhalerao, Luca Cucullo. A Guided Approach to Establish a Functional Humanized Brain-on-a-Chip Microfluidic Model of the Neurovascular System. In: Evangelia Papadimitriou, Constantinos M. Mikelis, eds. Methods in Cardiovascular and Lymphatic Biology. New York, NY: Springer US; 2025:35-52. https://doi.org/10.1007/978-1-0716-4706-6_4.

Katharina Stefanie Nitsche, Iris Müller, Sophie Malcomber, Paul Lawford Carmichael, Hans Bouwmeester. Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions. Frontiers in Toxicology. 2025;7. doi:10.3389/ftox.2025.1649393

Kristifor Sunderic, Andrew M. Wright, Nicole Kleinstreuer, et al. Complement-ARIE: Catalyzing the development and adoption of new approach methodologies. NAM Journal. 2025;1:100026. doi:10.1016/j.namjnl.2025.100026

K. Taylor, R. Ram, L. Ewart, et al. Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Frontiers in Drug Discovery. 2025;5. doi:10.3389/fddsv.2025.1536756

Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046