Experimental models of disease

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Alexandra Schaffert, Arti Ahluwalia, Jeffrey J. Bajramovic, et al. Finding a place for new approach methodologies (NAMs) in biomedical research. Lab Animal. 2026:1-11. doi:10.1038/s41684-026-01806-6
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Alison Marieann Veintimilla, Erika Moore. Endocrine effects in cell culture. Nature Reviews Bioengineering. 2026;4(8):697-698. doi:10.1038/s44222-026-00452-4
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Runxin Wu, Guinevere Ferreira, Nusrat Sadia Khan, et al. Digital twins and digital models of the human circulatory system. Nature Reviews Bioengineering. 2026;4(7):594-613. doi:10.1038/s44222-026-00427-5
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Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, et al. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nature Neuroscience. 2026:1-17. doi:10.1038/s41593-026-02367-0
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Lin Qi, Yuchen He, Alexandra Sviercovich, et al. Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies. Nature Biomedical Engineering. 2026:1-18. doi:10.1038/s41551-026-01618-6
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Lin Qi, Yuchen He, Alexandra Sviercovich, et al. Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies. Nature Biomedical Engineering. 2026:1-18. doi:10.1038/s41551-026-01618-6
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Mattia Ballerini, Serena Galiè, Punit Tyagi, et al. A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma. Nature Biomedical Engineering. 2025:1-18. doi:10.1038/s41551-024-01318-z
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Judit González-Gallego, Katalin Todorov-Völgyi, Stephan A. Müller, et al. A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. Nature Neuroscience. 2025:1-14. doi:10.1038/s41593-025-02123-w
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Gat Rauner, Piyush B. Gupta, Charlotte Kuperwasser. From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research. Nature Methods. 2025:1-12. doi:10.1038/s41592-025-02769-1
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Keitaro Kanie, Takeshi Ito, Genzo Iguchi, et al. Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid. Nature Communications. 2025;16(1):7900. doi:10.1038/s41467-025-63183-x
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