drug safety

M. Iveth Garcia, Keri Dame, Verena Charwat, et al. Human induced pluripotent stem cell-derived cardiomyocytes and their use in a cardiac organ-on-a-chip to assay electrophysiology, calcium and contractility. Nature Protocols. 2025:1-47. doi:10.1038/s41596-025-01166-4

Shivangi Shrimali, Minjun Chen, Dongying Li, Weida Tong. New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now? Drug Discovery Today. 2025:104452. doi:10.1016/j.drudis.2025.104452

Shivangi Shrimali, Minjun Chen, Dongying Li, Weida Tong. New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now? Drug Discovery Today. 2025;30(9):104452. doi:10.1016/j.drudis.2025.104452

Christopher E. Goldring, Giusy Russomanno, Carmen Pin, et al. Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety. Nature Reviews Drug Discovery. 2025:1-16. doi:10.1038/s41573-025-01308-z

Ruth A. Roberts, Mamta Behl, Helena T. Hogberg, et al. Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment. Drug Discovery Today. 2025;31(1):104569. doi:10.1016/j.drudis.2025.104569

Rodi Kado Abdalkader, Romanas Chaleckis, Takuya Fujita, Ken-ichiro Kamei. Modeling dry eye with an air–liquid interface in corneal epithelium-on-a-chip. Scientific Reports. 2024;14:4185. doi:10.1038/s41598-024-54736-z

Marius F. Harter, Timothy Recaldin, Regine Gerard, et al. Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids. Nature Biomedical Engineering. 2024;8:345-360. doi:10.1038/s41551-023-01156-5

Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, et al. Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Scientific Reports. 2021;11(1):6403. doi:10.1038/s41598-021-85708-2

Michael Balls, Jarrod Bailey, Robert D. Combes. How viable are alternatives to animal testing in determining the toxicities of therapeutic drugs? Expert Opinion on Drug Metabolism & Toxicology. 2019;15(12):985-987. doi:10.1080/17425255.2019.1694662