amyotrophic lateral sclerosis

Deepti Lall, Michael J. Workman, Samuel Sances, et al. An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier. Cell Stem Cell. 2025;32(7):1139-1153.e7. doi:10.1016/j.stem.2025.05.015

Christopher R. Bye, Elizabeth Qian, Katherine Lim, et al. Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. Nature Neuroscience. 2025:1-13. doi:10.1038/s41593-025-02118-7

Jakub Scaber, Iona Thomas-Wright, Alex J. Clark, et al. Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons. Stem Cell Reports. 2024;19(7):957-972. doi:10.1016/j.stemcr.2024.05.008

Louise Miny, Benoît G. C. Maisonneuve, Isabelle Quadrio, Thibault Honegger. Modeling Neurodegenerative Diseases Using In Vitro Compartmentalized Microfluidic Devices. Frontiers in Bioengineering and Biotechnology. 2022;10:919646. doi:10.3389/fbioe.2022.919646

Katarina Stoklund Dittlau, Emily N. Krasnow, Laura Fumagalli, et al. Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Reports. 2021;16(9):2213-2227. doi:10.1016/j.stemcr.2021.03.029

Terry C. Burns, Matthew D. Li, Swapnil Mehta, Ahmed J. Awad, Alexander A. Morgan. Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models. European Journal of Pharmacology. 2015;759:101-117. doi:10.1016/j.ejphar.2015.03.021