Alzheimer's disease

Ahmed Disouky, Mark A. Sanborn, K. R. Sabitha, et al. Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease. Nature. 2026:1-10. doi:10.1038/s41586-026-10169-4

Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, et al. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nature Neuroscience. 2026:1-17. doi:10.1038/s41593-026-02367-0

Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse, et al. Single-cell atlas of transcriptomic vulnerability across brain disorders. Nature. 2026;657(8133):988-1002. doi:10.1038/s41586-025-09573-z

Aram Aslanyan, Soumya Mukherjee, Eleanor M. Moncur, et al. Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue. Nature Communications. 2026;17(1):9878. doi:10.1038/s41467-026-76494-4

Cristina Dolciotti, Marco Righi, Eleonora Grecu, et al. The translational power of Alzheimer’s-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history. Frontiers in Cellular Neuroscience. 2025;19. doi:10.3389/fncel.2025.1553642

Leandro H. Gallo, Nesar Akanda, Kaveena Autar, et al. A functional aged human iPSC-cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics. Alzheimer’s & Dementia. 2024;20(9):5940-5960. doi:10.1002/alz.14044

Mariano I. Gabitto, Kyle J. Travaglini, Victoria M. Rachleff, et al. Integrated multimodal cell atlas of Alzheimer’s disease. Nature Neuroscience. 2024;27(12):2366-2383. doi:10.1038/s41593-024-01774-5

Sarnai Amartumur, Huong Nguyen, Thuy Huynh, et al. Neuropathogenesis-on-chips for neurodegenerative diseases. Nature Communications. 2024;15(1):2219. doi:10.1038/s41467-024-46554-8

Aliza P. Wingo, Yue Liu, Ekaterina S. Gerasimov, et al. Sex differences in brain protein expression and disease. Nature Medicine. 2023:1-9. doi:10.1038/s41591-023-02509-y

Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Peter J. K. Van Meer, et al. Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer’s disease. European Journal of Pharmacology. 2019;859:172524. doi:10.1016/j.ejphar.2019.172524