Translation and validation

Emily S. Sena, H. Bart van der Worp, Philip M. W. Bath, David W. Howells, Malcolm R. Macleod. Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy. PLOS Biology. 8(3):e1000344. doi:10.1371/journal.pbio.1000344

Constance Holman, Sophie K. Piper, Ulrike Grittner, et al. Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke. PLOS Biology. 14(1):e1002331. doi:10.1371/journal.pbio.1002331

H. Bart van der Worp, David W. Howells, Emily S. Sena, et al. Can Animal Models of Disease Reliably Inform Human Studies? PLOS Medicine. 7(3):e1000245. doi:10.1371/journal.pmed.1000245

Alper Öztürk, Halis Atıl Atilla. In Musculoskeletal Research, Too Many Animals are Being Harmed for Too Small a Return. Clinical Orthopaedics and Related Research. 482(5):899-900. doi:10.1097/CORR.0000000000003037

Clifford S. Deutschman. Translating Animal Studies to Human Disease: Language Matters*. Critical Care Medicine. 52(3):518-520. doi:10.1097/CCM.0000000000006167

Guilherme S. Ferreira, Désirée H. Veening-Griffioen, Wouter P. C. Boon, et al. A standardised framework to identify optimal animal models for efficacy assessment in drug development. PLOS ONE. 14(6):e0218014. doi:10.1371/journal.pone.0218014

Benjamin V. Ineichen, Eva Furrer, Servan L. Grüninger, Wolfgang E. Zürrer, Malcolm R. Macleod. Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications. PLOS Biology. 22(6):e3002667. doi:10.1371/journal.pbio.3002667

René Aquarius, Merel van de Voort, Hieronymus D. Boogaarts, P. Manon Reesink, Kimberley E. Wever. High prevalence of articles with image-related problems in animal studies of subarachnoid hemorrhage and low rates of correction by publishers. PLOS Biology. 23(10):e3003438. doi:10.1371/journal.pbio.3003438

Ken Getz MBA. How Much Does a Day of Delay in a Clinical Trial Really Cost? https://www.appliedclinicaltrialsonline.com/view/how-much-does-a-day-of-delay-in-a-clinical-trial-really-cost-.

Linda Bunschoten. The Real Cost of Delays in Drug Development and the Role of RBQM and QbD. https://cyntegrity.com/the-real-cost-of-delays-in-drug-development-and-the-role-of-rbqm-and-qbd.