Toxicology

Kyung-Jin Jang, Monicah A. Otieno, Janey Ronxhi, et al. Reproducing human and cross-species drug toxicities using a Liver-Chip. Science Translational Medicine. 2019;11(517):eaax5516. doi:10.1126/scitranslmed.aax5516

Rebecca L. Morgan, Paul Whaley, Kristina A. Thayer, Holger J. Schünemann. Identifying the PECO: A framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environment International. 2018;121:1027-1031. doi:10.1016/j.envint.2018.07.015

Samuel J. Jackson, Helen Prior, Anthony Holmes. The use of human tissue in safety assessment. Journal of Pharmacological and Toxicological Methods. 2018;93:29-34. doi:10.1016/j.vascn.2018.05.003

Nicole C. Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, et al. Non-animal methods to predict skin sensitization (II): an assessment of defined approaches. Critical Reviews in Toxicology. 2018;48(5):359-374. doi:10.1080/10408444.2018.1429386

Annamaria Carusi, Mark R. Davies, Giovanni De Grandis, et al. Harvesting the promise of AOPs: An assessment and recommendations. The Science of the Total Environment. 2018;628-629:1542-1556. doi:10.1016/j.scitotenv.2018.02.015

Jon Hamm, Kristie Sullivan, Amy J. Clippinger, et al. Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing. Toxicology in Vitro. 2017;41:245-259. doi:10.1016/j.tiv.2017.01.004

Jarrod Bailey, Michelle Thew, Michael Balls. Predicting human drug toxicity and safety via animal tests: can any one species predict drug toxicity in any other, and do monkeys help? Alternatives to laboratory animals: ATLA. 2015;43(6):393-403. doi:10.1177/026119291504300607

Dongeun Huh, Daniel C. Leslie, Benjamin D. Matthews, et al. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Science Translational Medicine. 2012;4(159). doi:10.1126/scitranslmed.3004249

Anna Herland, Ben M. Maoz, Debarun Das, et al. Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips. Nature Biomedical Engineering. 4(4):421-436. doi:10.1038/s41551-019-0498-9