Immune/infectious disease

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Longlong Si, Haiqing Bai, Melissa Rodas, et al. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nature Biomedical Engineering. 2021;5(8):815-829. doi:10.1038/s41551-021-00718-9
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Christopher Hopkins, Chidinma Onweni, Victoria Zambito, et al. Platforms for Personalized Polytherapeutics Discovery in COVID-19. Journal of Molecular Biology. 2021;433(10):166945. doi:10.1016/j.jmb.2021.166945
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Kevin G. Chen, Kyeyoon Park, Jason R. Spence. Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids. Nature Cell Biology. 2021;23(8):822-833. doi:10.1038/s41556-021-00721-x
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Min Zhang, Peng Wang, Ronghua Luo, et al. Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System. Advanced Science. 2021;8(3):2002928. doi:10.1002/advs.202002928
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Partho Protim Adhikary, Qurrat Ul Ain, Andreas Christian Hocke, Sarah Hedtrich. COVID-19 highlights the model dilemma in biomedical research. Nature Reviews Materials. 2021;6(5):374-376. doi:10.1038/s41578-021-00305-z
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Smriti Mallapaty. The mini lungs and other organoids helping to beat COVID. Nature. 2021;593(7860):492-494. doi:10.1038/d41586-021-01395-z
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A. L. Gard, R. J. Luu, C. R. Miller, et al. High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro. Scientific Reports. 2021;11(1):14961. doi:10.1038/s41598-021-94095-7
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Jelte van der Vaart, Mart M. Lamers, Bart L. Haagmans, Hans Clevers. Advancing lung organoids for COVID-19 research. Disease Models & Mechanisms. 2021;14(6):dmm049060. doi:10.1242/dmm.049060
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Alice Maria Giani, Shuibing Chen. Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery. Stem Cell Research. 2021;53:102207. doi:10.1016/j.scr.2021.102207
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Mart M. Lamers, Tim I. Breugem, Anna Z. Mykytyn, et al. Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7. 2021:2021.05.03.441080. doi:10.1101/2021.05.03.441080
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