Cardiovascular system

Bettina Lickiss, Jan Hunker, Jamie Bhagwan, et al. Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development. Journal of Pharmacological and Toxicological Methods. 2024;128:107529. doi:10.1016/j.vascn.2024.107529

Dennis M. Nahon, Marc Vila Cuenca, Francijna E. van den Hil, et al. Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes. Stem Cell Reports. 2024;19(7):946-956. doi:10.1016/j.stemcr.2024.05.006

Xuekun Wu, Kyle Swanson, Zehra Yildirim, Wenqiang Liu, Ronglih Liao, Joseph C Wu. Clinical trials in-a-dish for cardiovascular medicine. European Heart Journal. 2024;45(40):4275-4290. doi:10.1093/eurheartj/ehae519

Aleksandra Kostina, Yonatan R. Lewis-Israeli, Mishref Abdelhamid, et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports. 2024;19(3):317-330. doi:10.1016/j.stemcr.2024.01.003

Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, et al. Cardiac tissue model of immune-induced dysfunction reveals the role of free mitochondrial DNA and the therapeutic effects of exosomes. Science Advances. 2024;10(13):eadk0164. doi:10.1126/sciadv.adk0164

Evangelos P Daskalopoulos, Pierre Deceuninck, Maurice Whelan, Laura Gribaldo. Transition to innovative, human-relevant pre-clinical cardiovascular research: a perspective. Cardiovascular Research. 2024:cvae080. doi:10.1093/cvr/cvae080

Hongze Yin, Yue Wang, Na Liu, et al. Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip. Cyborg and Bionic Systems. 2024;5:0107. doi:10.34133/cbsystems.0107

Tromondae K. Feaster, Jourdan K. Ewoldt, Anna Avila, et al. Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues. Journal of Cardiovascular Electrophysiology. 2024;35(5):895-905. doi:10.1111/jce.16222

Inês Falcão-Pires. Alternatives to animal experimentation in cardiovascular research: human models of disease and biobanking. European Heart Journal. 2024;45(5):324-327. doi:10.1093/eurheartj/ehad709

Huub J. Weener, Heleen H. T. Middelkamp, Andries D. van der Meer. Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip. Frontiers in Toxicology. 2024;6. doi:10.3389/ftox.2024.1513002