Hans Clevers

Wim B. M. de Lau, Joost J. A. P. M. Wijnakker, Gijs J. F. van Son, et al. A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels. Nature Biotechnology. 2025:1-11. doi:10.1038/s41587-025-02874-8

Daisong Wang, Remi Villenave, Nadine Stokar-Regenscheit, Hans Clevers. Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges. Nature Reviews Drug Discovery. 2025:1-23. doi:10.1038/s41573-025-01317-y

Cun Li, Yifei Yu, Zhixin Wan, et al. Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction. Nature Communications. 2024;15(1):10772. doi:10.1038/s41467-024-55076-2

Amanda Andersson-Rolf, Kelvin Groot, Jeroen Korving, et al. Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages. Cell. 2024. doi:10.1016/j.cell.2024.10.044

Laura Rüland, Francesco Andreatta, Simone Massalini, et al. Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss. Nature Communications. 2023;14(1):2377. doi:10.1038/s41467-023-37951-6

Robert Jordan, Stephanie L Ford-Scheimer, Rodolfo M Alarcon, et al. Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development. The Journal of Infectious Diseases. 2023:jiad334. doi:10.1093/infdis/jiad334

Gui-Wei He, Lin Lin, Jeff DeMartino, et al. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell. 2022;29(9):1333-1345.e6. doi:10.1016/j.stem.2022.08.002

Shengli Ding, Carolyn Hsu, Zhaohui Wang, et al. Patient-derived micro-organospheres enable clinical precision oncology. Cell Stem Cell. 2022;29(6):905-917.e6. doi:10.1016/j.stem.2022.04.006

Jens Puschhof, Cayetano Pleguezuelos-Manzano, Hans Clevers. Organoids and organs-on-chips: Insights into human gut-microbe interactions. Cell Host & Microbe. 2021;29(6):867-878. doi:10.1016/j.chom.2021.04.002

Jens Puschhof, Cayetano Pleguezuelos-Manzano, Adriana Martinez-Silgado, et al. Intestinal organoid cocultures with microbes. Nature Protocols. 2021;16(10):4633-4649. doi:10.1038/s41596-021-00589-z