Translation and validation

Susan Bridgwood Green. Can animal data translate to innovations necessary for a new era of patient-centred and individualised healthcare? Bias in preclinical animal research. BMC Medical Ethics. 2015;16:53. doi:10.1186/s12910-015-0043-7

Terry C. Burns, Matthew D. Li, Swapnil Mehta, Ahmed J. Awad, Alexander A. Morgan. Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models. European Journal of Pharmacology. 2015;759:101-117. doi:10.1016/j.ejphar.2015.03.021

P Charukeshi Chandrasekera, John J Pippin. The human subject: an integrative animal model for 21st century heart failure research. American Journal of Translational Research. 2015;7(9):1636-1647. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626425/.

Isabella WY Mak, Nathan Evaniew, Michelle Ghert. Lost in translation: animal models and clinical trials in cancer treatment. American Journal of Translational Research. 2014;6(2):114-118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/.

Jeffrey L. Cummings, Travis Morstorf, Kate Zhong. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimer’s Research & Therapy. 2014;6:37. doi:10.1186/alzrt269

Pandora Pound, Michael B. Bracken. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ. 2014;348:g3387. doi:10.1136/bmj.g3387

Jarrod Bailey, Michelle Thew, Michael Balls. An analysis of the use of animal models in predicting human toxicology and drug safety. Alternatives to Laboratory Animals. 2014;42(3):181-199. doi:10.1177/026119291404200306

Fiona Godlee. How predictive and productive is animal research? BMJ. 2014;348:g3719. doi:10.1136/bmj.g3719

Jennifer A. Hirst, Jeremy Howick, Jeffrey K. Aronson, et al. The need for randomization in animal trials: an overview of systematic reviews. PloS One. 2014;9(6):e98856. doi:10.1371/journal.pone.0098856

Jarrod Bailey. Monkey-based research on human disease: the implications of genetic differences. Alternatives to Laboratory Animals. 2014;42(5):287-317. doi:10.1177/026119291404200504