Translation and validation

Pablo Perel, Ian Roberts, Emily Sena, et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ. 2007;334:197. doi:10.1136/bmj.39048.407928.BE

Victoria E. O’Collins, Malcolm R. Macleod, Geoffrey A. Donnan, Laura L. Horky, Bart H. van der Worp, David W. Howells. 1,026 experimental treatments in acute stroke. Annals of Neurology. 2006;59(3):467-477. doi:10.1002/ana.20741

Pandora Pound, Shah Ebrahim, Peter Sandercock, Michael B Bracken, Ian Roberts. Where is the evidence that animal research benefits humans? BMJ. 2004;328:514-517. doi:10.1136/bmj.328.7438.514

Peter J.K. van Meer, Marlous Kooijman, Christine C. Gispen-de Wied, Ellen H.M. Moors, Huub Schellekens. The ability of animal studies to detect serious post marketing adverse events is limited. Regulatory Toxicology and Pharmacology. 64(3):345-349. doi:10.1016/j.yrtph.2012.09.002

Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Validation Workgroup. Validation, Qualification, and Regulatory Acceptance of New Approach Methodologies. Interagency Coordinating Committee on the Validation of Alternative Methods; :75. https://ntp.niehs.nih.gov/sites/default/files/2024-03/VWG_Report_27Feb2024_FD_508.pdf.

Pandora Pound, Christine J. Nicol. Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions. PLOS ONE. 13(3):e0193758. doi:10.1371/journal.pone.0193758

Konstantinos K. Tsilidis, Orestis A. Panagiotou, Emily S. Sena, et al. Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases. PLOS Biology. 11(7):e1001609. doi:10.1371/journal.pbio.1001609

Nicole M. Llewellyn, Amber A. Weber, Clara M. Pelfrey, Deborah DiazGranados, Eric J. Nehl. Translating Scientific Discovery Into Health Policy Impact: Innovative Bibliometrics Bridge Translational Research Publications to Policy Literature. Academic Medicine. 98(8):896. doi:10.1097/ACM.0000000000005225

Emily S. Sena, H. Bart van der Worp, Philip M. W. Bath, David W. Howells, Malcolm R. Macleod. Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy. PLOS Biology. 8(3):e1000344. doi:10.1371/journal.pbio.1000344

Constance Holman, Sophie K. Piper, Ulrike Grittner, et al. Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke. PLOS Biology. 14(1):e1002331. doi:10.1371/journal.pbio.1002331