Cancer

Tianping Peng, Xiujian Ma, Wei Hua, et al. Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy. Cell Stem Cell. 2025. doi:10.1016/j.stem.2025.01.002

Mattia Ballerini, Serena Galiè, Punit Tyagi, et al. A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma. Nature Biomedical Engineering. 2025:1-18. doi:10.1038/s41551-024-01318-z

Sanjima Pal, Elee Shimshoni, Salvador Flores Torres, et al. Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology. Journal of Translational Medicine. 2025;23(1):577. doi:10.1186/s12967-025-06593-1

Yufei Wang, Limin Zhang, Louis Zizhao Wang, et al. The application of organoids in treatment decision-making for digestive system cancers: progress and challenges. Molecular Cancer. 2025;24(1):222. doi:10.1186/s12943-025-02429-0

Gat Rauner, Piyush B. Gupta, Charlotte Kuperwasser. From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research. Nature Methods. 2025:1-12. doi:10.1038/s41592-025-02769-1

Jihao Xu, Minh Duc Pham, Vincenzo Corbo, et al. Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology. Experimental & Molecular Medicine. 2025:1-9. doi:10.1038/s12276-024-01378-w

Mustafa Sibai, Sergi Cervilla, Daniela Grases, et al. The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity. Cell Reports. 2025;44(2). doi:10.1016/j.celrep.2024.115229

Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, et al. A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens. Nature Communications. 2025;16(1):1392. doi:10.1038/s41467-024-55129-6

Alice Scemama, Sophia Lunetto, Artysha Tailor, et al. Hybrid Cancer Stem Cells Utilise Vascular Tracks for Collective Streaming Invasion in a Metastasis-on-a-Chip Device.; 2024. doi:10.1101/2024.01.02.573897

Fei Tian, Dong Liu, Na Wei, et al. Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning. Nature Medicine. 2024:1-11. doi:10.1038/s41591-024-02915-w