Cancer

Enrique Podaza, Jared Capuano, Hui-Hsuan Kuo, et al. Tumor immune microenvironment reconstitution in patient-derived organoids enables therapy modeling for NSCLC. Cell Reports Methods. 2026;6(6). doi:10.1016/j.crmeth.2026.101339

Hui-Hsuan Kuo, Bhavneet Bhinder, Hamza N. Gokozan, et al. Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities. Science Advances. 2026;12(26):eadz3351. doi:10.1126/sciadv.adz3351

Pooja Sawant, Ratnesh Jain, Prajakta Dandekar. Emerging therapies for lung adenocarcinoma: Mechanistic and efficacy insights from spheroid-based <i>in vitro</i> models. Journal of Drug Delivery Science and Technology. 2026;117:108030. doi:10.1016/j.jddst.2026.108030

Jerome Lacombe, Sean E. Dunn, Marie Layac, et al. A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation. iScience. 2026;29(1). doi:10.1016/j.isci.2025.114236

Shivani Baisiwala, Elisa Fazzari, Matthew X. Li, et al. A human tumor-immune organoid model of glioblastoma. Cell Reports. 2026;45(1):116790. doi:10.1016/j.celrep.2025.116790

Weihong Ge, Ryan L. Kan, Can Yilgor, et al. Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1. Cell Reports. 2026;45(1):116848. doi:10.1016/j.celrep.2025.116848

Yufei Wang, Limin Zhang, Louis Zizhao Wang, et al. The application of organoids in treatment decision-making for digestive system cancers: progress and challenges. Molecular Cancer. 2025;24(1):222. doi:10.1186/s12943-025-02429-0

Gat Rauner, Piyush B. Gupta, Charlotte Kuperwasser. From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research. Nature Methods. 2025:1-12. doi:10.1038/s41592-025-02769-1

Sanjima Pal, Elee Shimshoni, Salvador Flores Torres, et al. Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology. Journal of Translational Medicine. 2025;23(1):577. doi:10.1186/s12967-025-06593-1

Mattia Ballerini, Serena Galiè, Punit Tyagi, et al. A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma. Nature Biomedical Engineering. 2025:1-18. doi:10.1038/s41551-024-01318-z