%0 Journal Article
%K Animal Testing Alternatives
%K Animals
%K Artificial intelligence
%K Biological Science Disciplines
%K Bioprinting
%K Digital Twins
%K High-throughput screening
%K Humans
%K Live-cell, high-content and real-time analysis
%K Microgravity and radiation simulators
%K microphysiological system
%K Primary cells and stem cells
%K Space Flight
%K Spheroids and organoids
%K systems biology
%B Biotechnology Advances
%D 2025
%G eng
%P 108574
%R 10.1016/j.biotechadv.2025.108574
%T Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research
%V 81
%8 2025
%! Taking the 3Rs to a higher level