%0 Journal Article %K cruelty-free %K key actions %B Frontiers in Toxicology %D 2025 %G English %R 10.3389/ftox.2025.1664209 %T Revisiting 3Rs: rethinking replacement and new approach methodologies %U https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2025.1664209/full %V 7 %8 2025-11-14 %! Revisiting 3Rs