TY - JOUR
KW - AI and ethics
KW - brain organoids
KW - microphysiological systems
KW - multiomics
KW - organoid-on-a-chip
AU - Aishwarya Pantula
AU - Kaustubh Joshi
AU - Swarangi Samant
AU - Greta Babakhanova
AU - Annie Kathuria
AB - Brain organoids are self-organizing 3D aggregates derived from pluripotent stem cells and thus mirror many aspects of human brain development, including gene expression programs, spatial organization, and neuron subtype specification. As a result, these organoids have been used to emulate neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. Yet, their maturation remains fundamentally constrained by diffusion-limited necrosis, incomplete vascularization, limited visualization, and the absence of large-scale circuit integration, which collectively prevent progression beyond the fetal stage. These intrinsic limitations have catalyzed a convergence across microfluidics, biofabrication, imaging, and ethical frameworks, giving rise to a multidisciplinary movement aimed at enhancing organoid viability, reproducibility, and physiological relevance. This perspective examines how these technologies are transforming brain organoids from developmental models into experimentally robust, functional platforms.
BT - Advanced Science
DO - 10.1002/advs.202523506
IS - n/a
LA - en
N2 - Brain organoids are self-organizing 3D aggregates derived from pluripotent stem cells and thus mirror many aspects of human brain development, including gene expression programs, spatial organization, and neuron subtype specification. As a result, these organoids have been used to emulate neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. Yet, their maturation remains fundamentally constrained by diffusion-limited necrosis, incomplete vascularization, limited visualization, and the absence of large-scale circuit integration, which collectively prevent progression beyond the fetal stage. These intrinsic limitations have catalyzed a convergence across microfluidics, biofabrication, imaging, and ethical frameworks, giving rise to a multidisciplinary movement aimed at enhancing organoid viability, reproducibility, and physiological relevance. This perspective examines how these technologies are transforming brain organoids from developmental models into experimentally robust, functional platforms.
EP - e23506
ST - Transforming Brain Organoids Into Functional Platforms
T2 - Advanced Science
TI - Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics
UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202523506
VL - n/a
Y2 - 2026-10-01
SN - 2198-3844
ER -