TY - ECHAP
KW - 3D bioprinting
KW - bioinks
KW - nonanimal methods
KW - Tissue engineering
KW - xeno-free models
AU - Ahmed S. M. Ali
AU - Dongwei Wu
AU - Jens Kurreck
AU - Catharine E. Krebs
AU - Gail A. Van Norman
AB - Three-dimensional (3D) bioprinting has emerged as an advanced technology at the intersection of biology, engineering, and materials science, offering unprecedented opportunities for improving healthcare, drug development, and regenerative medicine. This chapter explores core technologies—inkjet, extrusion, light-based systems, and volumetric printing—detailing their mechanisms, bioink requirements, and applications in cancer modeling, drug screening, and regenerative medicine. Natural, synthetic, and decellularized extracellular matrix-based bioinks are analyzed for their biocompatibility, mechanical properties, and ethical considerations, emphasizing the shift toward xeno-free models. Case studies show how bioprinted tissues better mimic human physiology than traditional models, including vascularized constructs and patient-specific disease platforms. Challenges such as scalability, vascular integration, and regulatory hurdles are addressed, alongside emerging innovations like artificial intelligence-driven optimization.
BT - Moving Toward Nonanimal Approaches in Medical Research and Testing
DA - 2027-01-01
N2 - Three-dimensional (3D) bioprinting has emerged as an advanced technology at the intersection of biology, engineering, and materials science, offering unprecedented opportunities for improving healthcare, drug development, and regenerative medicine. This chapter explores core technologies—inkjet, extrusion, light-based systems, and volumetric printing—detailing their mechanisms, bioink requirements, and applications in cancer modeling, drug screening, and regenerative medicine. Natural, synthetic, and decellularized extracellular matrix-based bioinks are analyzed for their biocompatibility, mechanical properties, and ethical considerations, emphasizing the shift toward xeno-free models. Case studies show how bioprinted tissues better mimic human physiology than traditional models, including vascularized constructs and patient-specific disease platforms. Challenges such as scalability, vascular integration, and regulatory hurdles are addressed, alongside emerging innovations like artificial intelligence-driven optimization.
PB - Academic Press
PY - 2027
SN - 978-0-443-26514-3
SP - 121
EP - 142
ST - Chapter 8 - 3D bioprinting as a promising alternative to animal models
T2 - Moving Toward Nonanimal Approaches in Medical Research and Testing
TI - Chapter 8 - 3D bioprinting as a promising alternative to animal models: Technologies and applications
UR - https://www.sciencedirect.com/science/article/pii/B9780443265143000187
Y2 - 2026-10-05
ER -