TY - ECHAP
KW - disease modeling
KW - Drug development
KW - microphysiological systems
KW - organ-on-chip
KW - organoids
AU - Konrad Schmidt
AU - Alessandro Bentivogli
AU - Sarah Hedtrich
AU - Catharine E. Krebs
AU - Gail A. Van Norman
AB - Microphysiological systems (MPS) are complex human-based in vitro models that aim to closely replicate human (patho)physiology. This chapter explores the current state-of-the-art and limitations of organoids and organ-on-chip (OoC) systems as preeminent MPS technologies. Organoids, self-assembled 3D cellular structures, closely mimic tissue-specific architecture and functions, advancing biomedical research in disease modeling, drug discovery, and personalized medicine. Complementing organoids, OoC systems integrate microfluidics and mechanical cues to recreate dynamic biological environments, addressing organ-specific and inter-organ interactions. Key aspects of OoC systems, including design principles, cell sources, and in situ monitoring, are highlighted for their potential to model complex diseases and pharmacokinetics. Despite their promise, MPS technologies face challenges such as limited complexity, scalability, and standardization, which hinder broader application. Nevertheless, by overcoming these constraints, MPS have the potential to improve biomedical research and reduce the usage of animal models in the future.
BT - Moving Toward Nonanimal Approaches in Medical Research and Testing
DA - 2027-01-01
N2 - Microphysiological systems (MPS) are complex human-based in vitro models that aim to closely replicate human (patho)physiology. This chapter explores the current state-of-the-art and limitations of organoids and organ-on-chip (OoC) systems as preeminent MPS technologies. Organoids, self-assembled 3D cellular structures, closely mimic tissue-specific architecture and functions, advancing biomedical research in disease modeling, drug discovery, and personalized medicine. Complementing organoids, OoC systems integrate microfluidics and mechanical cues to recreate dynamic biological environments, addressing organ-specific and inter-organ interactions. Key aspects of OoC systems, including design principles, cell sources, and in situ monitoring, are highlighted for their potential to model complex diseases and pharmacokinetics. Despite their promise, MPS technologies face challenges such as limited complexity, scalability, and standardization, which hinder broader application. Nevertheless, by overcoming these constraints, MPS have the potential to improve biomedical research and reduce the usage of animal models in the future.
PB - Academic Press
PY - 2027
SN - 978-0-443-26514-3
SP - 89
EP - 103
T2 - Moving Toward Nonanimal Approaches in Medical Research and Testing
TI - Chapter 6 - Microphysiological systems
UR - https://www.sciencedirect.com/science/article/pii/B9780443265143000023
Y2 - 2026-10-05
ER -