TY - JOUR
KW - Alzheimer's disease
KW - amyotrophic lateral sclerosis
KW - Huntington's disease
KW - Neurodegeneration
KW - Parkinson's disease
AU - Sarnai Amartumur
AU - Huong Nguyen
AU - Thuy Huynh
AU - Testaverde S. Kim
AU - Ran-Sook Woo
AU - Eungseok Oh
AU - Kyeong Kyu Kim
AU - Luke P. Lee
AU - Chaejeong Heo
AB - Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.
BT - Nature Communications
DA - 2024-03-12
DO - 10.1038/s41467-024-46554-8
IS - 1
LA - en
N2 - Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.
PY - 2024
EP - 2219
T2 - Nature Communications
TI - Neuropathogenesis-on-chips for neurodegenerative diseases
UR - https://www.nature.com/articles/s41467-024-46554-8
VL - 15
Y2 - 2026-08-14
SN - 2041-1723
ER -