TY - JOUR KW - Biomaterials – proteins KW - Drug development KW - Drug screening KW - Tissue engineering KW - translational research AU - Mariana Dias AU - Catarina A. Custódio AU - João F. Mano AB - Human protein-based biomaterials facilitate the development of preclinical models that integrate predictive value and ethical responsibility. Metatissue uses decellularized extracellular matrix from placenta samples and human blood to create tunable, xeno-free substrates for 3D cell culture, minimizing the reliance on animal models and accelerating translational research. BT - Nature Reviews Bioengineering DA - 2026-05 DO - 10.1038/s44222-026-00425-7 IS - 5 LA - en N2 - Human protein-based biomaterials facilitate the development of preclinical models that integrate predictive value and ethical responsibility. Metatissue uses decellularized extracellular matrix from placenta samples and human blood to create tunable, xeno-free substrates for 3D cell culture, minimizing the reliance on animal models and accelerating translational research. PY - 2026 SP - 399 EP - 400 T2 - Nature Reviews Bioengineering TI - Human protein-based biomaterials in preclinical modelling UR - https://www.nature.com/articles/s44222-026-00425-7 VL - 4 Y2 - 2026-08-12 SN - 2731-6092 ER -