TY - JOUR
KW - Biological techniques
KW - Cell biology
KW - Developmental biology
KW - medical research
KW - Physiology
AU - Cristina Antich
AU - Yu-Chi Chen
AU - Justine Noel
AU - Yanyan Qu
AU - Yuhong Fang
AU - Shayne Frebert
AU - Dingyin Tao
AU - Lauren S. Richardson
AU - Ramkumar Menon
AU - Min Jae Song
AU - Marc Ferrer
AB - The placenta is a highly dynamic organ that supports the growth and development of the fetus during gestation. Malfunction of the placenta causes disorders of the pregnancy, including preeclampsia and pre-term birth. The study of the pathophysiology of the placenta throughout pregnancy has been hindered by limited access to the human placenta and lack of predictive cellular and animal models. Here, we describe 3D bioprinted human placenta barrier (hPB) tissue models using primary human trophoblasts and stroma cells that recapitulate the physiology of the human placenta at early and late stages of gestation. These bioprinted vascularized hPB tissue models mimic the architecture and function early and late-stages human placenta, including barrier function, nutrient uptake, transporters activity and hormones secretion. Assembled in a 96-well transwell plate format, this deeply characterized platform provides a robust high-fidelity system for predictive screening of therapeutics and potentially hazardous agents for placenta diseases and safety, and a better understanding of placental pathophysiology.
BT - Scientific Reports
DA - 2026-07-28
DO - 10.1038/s41598-026-61708-y
IS - 1
LA - en
N2 - The placenta is a highly dynamic organ that supports the growth and development of the fetus during gestation. Malfunction of the placenta causes disorders of the pregnancy, including preeclampsia and pre-term birth. The study of the pathophysiology of the placenta throughout pregnancy has been hindered by limited access to the human placenta and lack of predictive cellular and animal models. Here, we describe 3D bioprinted human placenta barrier (hPB) tissue models using primary human trophoblasts and stroma cells that recapitulate the physiology of the human placenta at early and late stages of gestation. These bioprinted vascularized hPB tissue models mimic the architecture and function early and late-stages human placenta, including barrier function, nutrient uptake, transporters activity and hormones secretion. Assembled in a 96-well transwell plate format, this deeply characterized platform provides a robust high-fidelity system for predictive screening of therapeutics and potentially hazardous agents for placenta diseases and safety, and a better understanding of placental pathophysiology.
PY - 2026
EP - 24140
ST - Recapitulating gestational progression
T2 - Scientific Reports
TI - Recapitulating gestational progression: a high-throughput 3D bioprinted vascularized human placenta demonstrating stage-specific molecular and functional signatures of human pregnancy
UR - https://www.nature.com/articles/s41598-026-61708-y
VL - 16
Y2 - 2026-08-06
SN - 2045-2322
ER -