TY - JOUR
KW - cardiac microtissues
KW - Cardiorenal axis
KW - Drug-induced toxicity
KW - Inter-organ interaction
KW - Kidney organoids
AU - Beatrice Gabbin
AU - James Gallant
AU - Fangchen Liu
AU - Hailiang Mei
AU - Berend J. van Meer
AU - Ton J. Rabelink
AU - Christine L. Mummery
AU - Jessica M. Vanslambrouck
AU - Cathelijne W. van den Berg
AU - Viviana Meraviglia
AU - Milena Bellin
AB - The bidirectional communication between the heart and kidney is essential for physiological homeostasis, with injury in one organ often impairing the other. Although cardiorenal crosstalk is clinically relevant in conditions such as cardiorenal syndrome (CRS), the underlying molecular and cellular mechanisms remain poorly understood, and in vitro models are lacking. Here, we developed a co-culture system using human induced pluripotent stem cell (hiPSC)-derived kidney organoids (kOs) and cardiac microtissues (cMTs) to model the cardiorenal axis.
BT - Cell Communication and Signaling
DA - 2026-05-06
DO - 10.1186/s12964-026-02902-3
IS - 1
LA - en
N2 - The bidirectional communication between the heart and kidney is essential for physiological homeostasis, with injury in one organ often impairing the other. Although cardiorenal crosstalk is clinically relevant in conditions such as cardiorenal syndrome (CRS), the underlying molecular and cellular mechanisms remain poorly understood, and in vitro models are lacking. Here, we developed a co-culture system using human induced pluripotent stem cell (hiPSC)-derived kidney organoids (kOs) and cardiac microtissues (cMTs) to model the cardiorenal axis.
PY - 2026
EP - 380
T2 - Cell Communication and Signaling
TI - In vitro modeling of renal injury-induced cardiac effects using human iPSC-derived organoids
UR - https://doi.org/10.1186/s12964-026-02902-3
VL - 24
Y2 - 2026-07-16
SN - 1478-811X
ER -