TY - JOUR
KW - sexual dimorphism
KW - autoimmune disorders
KW - diet
KW - Gender
KW - gut microbiome
KW - Humans
KW - Immunity
KW - Mice
KW - sex hormones
AU - Jean S. McGee
AU - Curtis Huttenhower
AB - The gut microbiome plays a critical role in developing and educating our immune system. Therefore, its now well-established role in autoimmunity and immune disorders is in some ways not surprising. However, it is well-documented in the literature that there is a female predisposition to autoimmune disorders, while sexual dimorphisms in the human microbiome have been confined largely to areas outside of the gut. Herein, we will review the evidence of sexual dimorphism in the gut microbiome in both mice and humans, how this differs in animal models versus humans, and how such dimorphisms may be established and influenced by both host and environmental factors. We will conclude with a discussion on how these aspects of the gut microbiome may contribute to both the study and pathogenesis of gender-specific autoimmunity and immune disorders.
BT - International Journal of Women's Dermatology
DA - 2021-12-01
DO - 10.1016/j.ijwd.2021.10.007
IS - 5, Part A
N2 - The gut microbiome plays a critical role in developing and educating our immune system. Therefore, its now well-established role in autoimmunity and immune disorders is in some ways not surprising. However, it is well-documented in the literature that there is a female predisposition to autoimmune disorders, while sexual dimorphisms in the human microbiome have been confined largely to areas outside of the gut. Herein, we will review the evidence of sexual dimorphism in the gut microbiome in both mice and humans, how this differs in animal models versus humans, and how such dimorphisms may be established and influenced by both host and environmental factors. We will conclude with a discussion on how these aspects of the gut microbiome may contribute to both the study and pathogenesis of gender-specific autoimmunity and immune disorders.
PY - 2021
SP - 533
EP - 538
ST - Of mice and men and women
T2 - International Journal of Women's Dermatology
TI - Of mice and men and women: Sexual dimorphism of the gut microbiome
UR - https://www.sciencedirect.com/science/article/pii/S2352647521001295
VL - 7
Y2 - 2026-06-03
SN - 2352-6475
ER -